(Q44036518)

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Thiol protecting agents and antioxidants inhibit the mitochondrial permeability transition promoted by etoposide: implications in the prevention of etoposide-induced apoptosis

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scholarly article

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Europe PubMed Central

29 November 2017

Thiol protecting agents and antioxidants inhibit the mitochondrial permeability transition promoted by etoposide: implications in the prevention of etoposide-induced apoptosis (English)

1 reference

Europe PubMed Central

29 November 2017

1 reference

based on heuristic

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José B. Custódio

1

1 reference

Europe PubMed Central

29 November 2017

Leonor M. Almeida

3

1 reference

Europe PubMed Central

29 November 2017

author name string

Carla M P Cardoso

2

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Europe PubMed Central

29 November 2017

publication date

1 May 2002

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Europe PubMed Central

29 November 2017

Chemico-biological Interactions

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Europe PubMed Central

29 November 2017

140

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Europe PubMed Central

29 November 2017

2

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Europe PubMed Central

29 November 2017

169-184

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Europe PubMed Central

29 November 2017

Etoposide (VP-16-213). Current status of an active anticancer drug

1 reference

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7 January 2021

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR Study

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7 January 2021

Ascorbate is the primary reductant of the phenoxyl radical of etoposide in the presence of thiols both in cell homogenates and in model systems.

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Distinct pathways for stimulation of cytochrome c release by etoposide

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Mitochondrial permeability transition induced by the anticancer drug etoposide

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Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

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Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

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7 January 2021

Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential

1 reference

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7 January 2021

PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

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Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition.

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7 January 2021

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death.

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The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

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Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition

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Nitric oxide production and mitochondrial dysfunction during rat thymocyte apoptosis

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Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide

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7 January 2021

Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress

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Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

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Triggering and modulation of apoptosis by oxidative stress

1 reference

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Separation of cytochrome c-dependent caspase activation from thiol-disulfide redox change in cells lacking mitochondrial DNA.

1 reference

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7 January 2021

Tamoxifen inhibits induction of the mitochondrial permeability transition by Ca2+ and inorganic phosphate

1 reference

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Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state

1 reference

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7 January 2021

A rapid and ultrasensitive method to measure Ca++ movements across biological membranes

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Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity

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7 January 2021

Antioxidant paradoxes of phenolic compounds: peroxyl radical scavenger and lipid antioxidant, etoposide (VP-16), inhibits sarcoplasmic reticulum Ca(2+)-ATPase via thiol oxidation by its phenoxyl radical

1 reference

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7 January 2021

Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates

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7 January 2021

The thiol-specific antioxidant enzyme prevents mitochondrial permeability transition. Evidence for the participation of reactive oxygen species in this mechanism

1 reference

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7 January 2021

The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal

1 reference

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7 January 2021

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

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The mitochondrial permeability transition.

1 reference

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Mitochondria-mediated cell injury. Symposium overview

1 reference

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The mitochondrial permeability transition

1 reference

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7 January 2021

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

1 reference

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7 January 2021

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1 reference

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7 January 2021

Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

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Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

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Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

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Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides.

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7 January 2021

Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions. A proposed model for phosphate-stimulated lipid peroxidation.

1 reference

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7 January 2021

Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A.

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7 January 2021

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition.

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Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation

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Glutathione, oxidative stress and neurodegeneration

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Review: The role of glutathione in the regulation of apoptosis

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Induction of the mitochondrial permeability transition by N-ethylmaleimide depends on secondary oxidation of critical thiol groups. Potentiation by copper-ortho-phenanthroline without dimerization of the adenine nucleotide translocase

1 reference

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Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy

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Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death

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Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.

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Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes.

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7 January 2021

Identifiers

10.1016/S0009-2797(02)00020-0

1 reference

Europe PubMed Central

29 November 2017

1 reference

Europe PubMed Central

29 November 2017

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