(Q44058777)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

title

Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

author name string

Yasuhiro Koh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Shintaro Matsumi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Debananda Das

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

David A Davis

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Jianfeng Li

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Sofiya Leschenko

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Abigail Baldridge

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Tatsuo Shioda

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Robert Yarchoan

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Arun K Ghosh

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Hiroaki Mitsuya

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

language of work or name

English

0 references

publication date

17 July 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

2 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

volume

282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

issue

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

page(s)

28709-28720

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

HIV-1 dynamics in vivo: implications for therapy

2 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Toxicity of antiretroviral therapy and implications for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Active human immunodeficiency virus protease is required for viral infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: rethinking the "fireman's grip" hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

The folding and dimerization of HIV-1 protease: evidence for a stable monomer from simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Switching between allosteric and dimerization inhibition of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Disruption of the HIV-1 protease dimer with interface peptides: structural studies using NMR spectroscopy combined with [2-(13)C]-Trp selective labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

PCR-mediated recombination: a general method applied to construct chimeric infectious molecular clones of plasma-derived HIV-1 RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Folded monomer of HIV-1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug r

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Unique Thermodynamic Response of Tipranavir to Human Immunodeficiency Virus Type 1 Protease Drug Resistance Mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

Concomitant use of an active boosted protease inhibitor with enfuvirtide in treatment-experienced, HIV-infected individuals: recent data and consensus recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703938200

21 January 2018

Identifiers

DOI

10.1074/JBC.M703938200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference