(Q44076450)

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Pharmacokinetic modeling to assess factors affecting the oral bioavailability of the lactone and carboxylate forms of the lipophilic camptothecin analogue AR-67 in rats

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1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Pharmacokinetic modeling to assess factors affecting the oral bioavailability of the lactone and carboxylate forms of the lipophilic camptothecin analogue AR-67 in rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

bioavailability

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Eyob D Adane

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Zhiwei Liu

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Tian-Xiang Xiang

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Bradley D Anderson

4

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Markos Leggas

5

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

publication date

9 November 2011

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

29

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

1722-1736

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity.

1 reference

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21 January 2018

A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies

1 reference

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21 January 2018

Phase I and pharmacokinetic study of gimatecan given orally once a week for 3 of 4 weeks in patients with advanced solid tumors

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Efficacy and toxicity of belotecan with and without cisplatin in patients with recurrent ovarian cancer

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Patient preferences for oral versus intravenous palliative chemotherapy

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Phase III study comparing oral topotecan to intravenous docetaxel in patients with pretreated advanced non-small-cell lung cancer

1 reference

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Oral topotecan as single-agent second-line chemotherapy in patients with advanced ovarian cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

A phase I dose-finding clinical pharmacokinetic study of an oral formulation of irinotecan (CPT-11) administered for 5 days every 3 weeks in patients with advanced solid tumours

1 reference

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21 January 2018

Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues

1 reference

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21 January 2018

Stable supersaturated aqueous solutions of silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin via chemical conversion in the presence of a chemically modified beta-cyclodextrin

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

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Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo

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Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid

1 reference

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21 January 2018

Dependence of nelfinavir brain uptake on dose and tissue concentrations of the selective P-glycoprotein inhibitor zosuquidar in rats

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Misuse of the well-stirred model of hepatic drug clearance.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Factors affecting the in vivo lactone stability and systemic clearance of the lipophilic camptothecin analogue AR-67.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

A novel extravascular input function for the assessment of drug absorption in bioavailability studies.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

A note on population analysis of dissolution-absorption models using the inverse Gaussian function

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

The utility of cyclodextrins for enhancing oral bioavailability

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

The "albumin effect" and in vitro-in vivo extrapolation: sequestration of long-chain unsaturated fatty acids enhances phenytoin hydroxylation by human liver microsomal and recombinant cytochrome P450 2C9.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Overexpression of OATP1B3 confers apoptotic resistance in colon cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Efficacy of the novel camptothecin gimatecan against orthotopic and metastatic human tumor xenograft models

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0617-0

21 January 2018

Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological parameters in laboratory animals and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interpatient variability in bioavailability of the intravenous formulation of topotecan given orally to children with recurrent solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic trial of oral irinotecan administered daily for 5 days every 3 weeks in patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct translation of a protracted irinotecan schedule from a xenograft model to a phase I trial in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/22068278

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of a transmembrane protein on the permeability of small molecules across lipid membranes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors

1 reference

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12 December 2020

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Identifiers

10.1007/S11095-011-0617-0

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

release_mgi4tch4wbc2fbhn36xyjobpcq

1 reference

https://api.fatcat.wiki/v0/release/mgi4tch4wbc2fbhn36xyjobpcq

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

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