(Q44102100)

English

Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir

scientific article published on 9 August 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

(-)-carbovir 5'-monophosphate

1 reference

ChEBI release 2020-05-28

1

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

author name string

Aravind Basavapathruni

2

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Karen S Anderson

3

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

language of work or name

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publication date

9 August 2002

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

number of pages

12

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

277

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

43

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

40479-40490

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

The accuracy of reverse transcriptase from HIV-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Fidelity of HIV-1 reverse transcriptase copying RNA in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Current knowledge of HIV-1 reverse transcriptase mutations selected during nucleoside analogue therapy: the potential to use resistance data to guide clinical decisions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Luminescent immobilized enzyme test systems for inorganic pyrophosphate: assays using firefly luciferase and nicotinamide-mononucleotide adenylyl transferase or adenosine-5'-triphosphate sulfurylase

1 reference

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21 January 2018

Physiological concentrations of purines and pyrimidines

1 reference

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21 January 2018

Novel use of a guanosine prodrug approach to convert 2',3'-didehydro-2',3'-dideoxyguanosine into a viable antiviral agent

1 reference

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21 January 2018

Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group

1 reference

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21 January 2018

Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408.

1 reference

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21 January 2018

Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection

1 reference

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21 January 2018

Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine

1 reference

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21 January 2018

Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism

1 reference

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21 January 2018

Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.

1 reference

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21 January 2018

Prediction of abacavir resistance from genotypic data: impact of zidovudine and lamivudine resistance in vitro and in vivo

1 reference

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21 January 2018

Salvage therapy with abacavir plus a non-nucleoside reverse transcriptase inhibitor and a protease inhibitor in heavily pre-treated HIV-1 infected patients. Swiss HIV Cohort Study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

1 reference

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21 January 2018

The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205303200

21 January 2018

Evaluation of human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy: specificity and comparison to primer/template binding

1 reference

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21 January 2018

Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nuc

1 reference

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21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

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21 January 2018

Mechanistic studies to understand the inhibition of wild type and mutant HIV-1 reverse transcriptase by Carbovir-triphosphate

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21 January 2018

Involvement of calcium inhibitable binding to the cell wall in the fungicidal activity of CAN-296

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Fidelity analysis of HIV-1 reverse transcriptase mutants with an altered amino-acid sequence at residues Leu74, Glu89, Tyr115, Tyr183 and Met184.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M205303200

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

ResearchGate publication ID

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