(Q43773229)

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The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.

scientific article published on 19 October 2001

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Europe PubMed Central

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13 November 2019

The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase (English)

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13 November 2019

5

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13 November 2019

1

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13 November 2019

author name string

Ehresmann C

2

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13 November 2019

Walter P

3

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13 November 2019

Ehresmann B

4

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13 November 2019

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19 October 2001

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13 November 2019

Journal of Biological Chemistry

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13 November 2019

276

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13 November 2019

52

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13 November 2019

48725-48732

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13 November 2019

Phenotypic and genotypic resistance patterns of HIV-1 isolates derived from individuals treated with didanosine and stavudine.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

The accuracy of reverse transcriptase from HIV-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Efficacy and tolerability of stavudine plus lamivudine in treatment-naive and treatment-experienced patients with HIV-1 infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

The crystal structure of HIV reverse-transcription primer tRNA(Lys,3) shows a canonical anticodon loop

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Luminescent immobilized enzyme test systems for inorganic pyrophosphate: assays using firefly luciferase and nicotinamide-mononucleotide adenylyl transferase or adenosine-5'-triphosphate sulfurylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Implication of the tRNA initiation step for human immunodeficiency virus type 1 reverse transcriptase in the mechanism of 3'-azido-3'-deoxythymidine (AZT) resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108352200

21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

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21 January 2018

Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase

1 reference

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21 January 2018

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