(Q44115018)

English

In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway.

scientific article published in September 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 November 2017

In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

1 reference

based on heuristic

inferred from title

toxic encephalopathy

1 reference

based on heuristic

inferred from title

BethAnn McLaughlin

2

object named as

BethAnn McLaughlin

0 references

author name string

Shen Du

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

BethAnn McLaughlin

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

Sumon Pal

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

Elias Aizenman

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

1 September 2002

1 reference

Europe PubMed Central

PubMed publication ID

29 November 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

7408-7416

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

NADPH oxidase: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ERK/MAP-kinases cascade in the nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol myristate acetate induces neutrophil NADPH-oxidase activity by two separate signal transduction pathways: dependent or independent of phosphatidylinositol 3-kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicologic evidence of developmental neurotoxicity of environmental chemicals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial cell oxidant production: effect of NADPH oxidase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Neuronal Apoptosis by Thiol Oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomics: implications for toxicology

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FMLP-induced formation of F-actin in HL60 cells is dependent on PI3-K but not on intracellular Ca2+, PKC, ERK or p38 MAPK

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoxygenases and their involvement in programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The action of CGS-19755 on the redox enhancement of NMDA toxicity in rat cortical neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Evaluation of humidifier units within the scope of room climate modification]

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical reactivity of some isothiazolone biocides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kathon CG and cosmetic products

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel biologically active seleno-organic compound—1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of 12-lipoxygenase mRNA in cultured oligodendrocytes and astrocytes by in situ reverse transcriptase and polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces apoptosis in embryonic cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and protein distribution of 12-lipoxygenase in HEL cells: induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca(2+)-dependent translocation to membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of multiple kinases in neutrophil activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple chemical sensitivity disorder in patients with neurotoxic illnesses

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc (Zn2+) binds to and stimulates the activity of group I but not group II phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three cases of contact allergy after chemical burns from methylchloroisothiazolinone/methylisothiazolinone: one with concomitant allergy to methyldibromoglutaronitrile/phenoxyethanol

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two case reports of delayed skin burns from methylisothiazolines used in water treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation of neuronal apoptosis by enhancement of outward potassium current.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of poly(ADP-ribose) polymerase: reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: a brief overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-17-07408.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6757960&resulttype=core&format=json

12 May 2020

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