(Q44117864)

30 November 2017

High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion (English)

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30 November 2017

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30 November 2017

3

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30 November 2017

Cotter TG

2

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PubMed ID

12200687

30 November 2017

language of work or name

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1 September 2002

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30 November 2017

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30 November 2017

16

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30 November 2017

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30 November 2017

1725-1734

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402576

30 November 2017

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cites work

Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

The Bcl-2 protein family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

The substitution of the C-terminus of bax by that of bcl-xL does not affect its subcellular localization but abrogates its pro-apoptotic properties.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Conversion of Bcl-2 to a Bax-like death effector by caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Breaking the mitochondrial barrier

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

An in vivo and in vitro comparison of the effects of b2-a2 and b3-a2 p210BCR-ABL splice variants on murine 32D cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Apoptosis in chronic myelogenous leukemia: studies of stage-specific differences.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL--expressing cells, demonstrating synergy between AG490 and STI571.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Conformation of the Bax C-terminus regulates subcellular location and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402576

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402576

1 reference

PubMed ID

12200687

Dimensions Publication ID

30 November 2017

0 references

1 reference

PubMed ID

12200687