(Q44126827)

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1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats.

scientific article published in September 2002

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12 November 2019

1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats (English)

1 reference

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12 November 2019

Waldemar A. Turski

3

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12 November 2019

4

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12 November 2019

Piotr Luchowski

1

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Piotr Luchowski

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12 November 2019

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Elzbieta Luchowska

2

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12 November 2019

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1 September 2002

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12 November 2019

Neuroscience Letters

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12 November 2019

330

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12 November 2019

1

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12 November 2019

49-52

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12 November 2019

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

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Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: reversal by lactate and pyruvate.

1 reference

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.

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Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

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Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

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Inhibition of energy metabolism by 3-nitropropionic acid activates ATP-sensitive potassium channels

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7 January 2021

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Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum.

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Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss.

1 reference

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7 January 2021

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Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection

1 reference

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7 January 2021

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Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

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7 January 2021

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Excitatory amino acid antagonists protect mice against MPP+ seizures

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7 January 2021

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Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine

1 reference

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7 January 2021

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Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice

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AMPA/kainate-related mechanisms contribute to convulsant and proconvulsant effects of 3-nitropropionic acid

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Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.

1 reference

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7 January 2021

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NMDA receptor involvement in toxicity to dopamine neurons in vitro caused by the succinate dehydrogenase inhibitor 3-nitropropionic acid.

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7 January 2021

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Identifiers

10.1016/S0304-3940(02)00735-8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12213632%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

Europe PubMed Central

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12 November 2019

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