(Q44133868)

30 November 2017

title

Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion (English)

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30 November 2017

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Zhi-Liang Wu

1

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30 November 2017

Teresa M O'Kane

2

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30 November 2017

Richard W Scott

3

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30 November 2017

Mary J Savage

4

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30 November 2017

Donna Bozyczko-Coyne

5

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30 November 2017

language of work or name

English

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publication date

10 September 2002

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Journal of Biological Chemistry

30 November 2017

number of pages

6

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based on heuristic

inferred from page(s)

published in

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30 November 2017

volume

277

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30 November 2017

issue

46

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30 November 2017

page(s)

44208-44213

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Glutamine repeats and neurodegeneration

30 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206890200

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

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Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

21 January 2018

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A cellular model that recapitulates major pathogenic steps of Huntington's disease

21 January 2018

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The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M206890200

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M206890200

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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Early alterations in gene expression and cell morphology in a mouse model of Huntington's disease.

21 January 2018

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Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

21 January 2018

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CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

21 January 2018

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Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M206890200

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206890200

Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M206890200

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206890200

Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M206890200

A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation

21 January 2018

1 reference

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Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M206890200

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30 November 2017

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