(Q44142327)

30 November 2017

title

Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach (English)

1 reference

30 November 2017

4

Raymond F Schinazi

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30 November 2017

5

Chung K Chu

1 reference

30 November 2017

1

Youhoon Chong

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30 November 2017

3

Phillip A Furman

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30 November 2017

Katyna Borroto-Esoda

2

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30 November 2017

language of work or name

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1 March 2002

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Antiviral Chemistry & Chemotherapy

30 November 2017

published in

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30 November 2017

volume

13

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30 November 2017

issue

2

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30 November 2017

page(s)

115-128

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

30 November 2017

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Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase

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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

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Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

21 January 2018

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Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the International AIDS Society-USA panel

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The nucleoside deaminases for cytidine and adenosine: Structure, transition state stabilization, mechanism, and evolution

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Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

21 January 2018

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Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

21 January 2018

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

21 January 2018

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Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine

21 January 2018

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

21 January 2018

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Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

21 January 2018

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Modelling of purine nucleoside metabolism during mouse embryonic development: relative routes of adenosine, deoxyadenosine, and deoxyguanosine metabolism.

21 January 2018

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Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine

21 January 2018

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Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

21 January 2018

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Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity

21 January 2018

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1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes

21 January 2018

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Molecular mechanisms of antiviral resistance

21 January 2018

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Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

21 January 2018

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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

21 January 2018

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Closing in on HIV drug resistance.

21 January 2018

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3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

21 January 2018

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Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents

21 January 2018

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Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails

21 January 2018

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

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Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

21 January 2018

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A Comparison of the Conformations of the 5′-Triphosphates of Zidovudine (AZT) and Thymidine Bound to HIV-1 Reverse Transcriptase

21 January 2018

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The accuracy of reverse transcriptase from HIV-1.

21 January 2018

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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

21 January 2018

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Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

21 January 2018

1 reference

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Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

21 January 2018

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Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

21 January 2018

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Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

21 January 2018

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Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

21 January 2018

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An all atom force field for simulations of proteins and nucleic acids

21 January 2018

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Regulation of the reverse transcriptase of human immunodeficiency virus type 1 by dNTPs

21 January 2018

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10.1177/095632020201300205

21 January 2018

Identifiers

DOI

1 reference

30 November 2017

1 reference