(Q44158321)

30 November 2017

title

Dynamics and binding modes of free cdk2 and its two complexes with inhibitors studied by computer simulations (English)

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30 November 2017

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1

Michal Otyepka

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30 November 2017

3

Jaroslav Koca

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30 November 2017

Zdenek Kríz

2

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30 November 2017

publication date

1 October 2002

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Journal of Biomolecular Structure and Dynamics

30 November 2017

published in

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30 November 2017

volume

20

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30 November 2017

issue

2

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30 November 2017

page(s)

141-154

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Cyclin-dependent kinases: engines, clocks, and microprocessors

30 November 2017

cites work

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Structural basis for control by phosphorylation

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

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Inhibition of cyclin-dependent kinases by purine analogues

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Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles

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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

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Characterization of novel inhibitors of cyclin-dependent kinases

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Small-molecule inhibitors of the cell cycle

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Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

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The dynamics of cyclin dependent kinase structure

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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Structural basis of cyclin-dependent kinase activation by phosphorylation

21 January 2018

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Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

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Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2

21 January 2018

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Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

21 January 2018

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Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717

21 January 2018

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Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex

21 January 2018

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10.1080/07391102.2002.10506830

21 January 2018

Identifiers

DOI

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30 November 2017

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