(Q44193818)

English

Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase.

scientific article published on 23 October 2002

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scholarly article

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14 December 2019

Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase (English)

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14 December 2019

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14 December 2019

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14 December 2019

author name string

Tony Velkov

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30 November 2017

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publication date

23 October 2002

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14 December 2019

Journal of Biological Chemistry

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14 December 2019

278

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14 December 2019

2

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14 December 2019

1137-1148

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14 December 2019

Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity

1 reference

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21 January 2018

Immunomodulation: particular perspectives

1 reference

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21 January 2018

Current treatment practice in immunosuppression

1 reference

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21 January 2018

Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin

1 reference

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21 January 2018

Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages

1 reference

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21 January 2018

Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin.

1 reference

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21 January 2018

Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction

1 reference

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21 January 2018

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1 reference

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21 January 2018

Protein templates for the biosynthesis of peptide antibiotics

1 reference

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21 January 2018

Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA.

1 reference

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21 January 2018

How do peptide synthetases generate structural diversity?

1 reference

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21 January 2018

The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame

1 reference

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21 January 2018

Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain.

1 reference

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21 January 2018

Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyldepsipeptide formation in Fusarium scirpi

1 reference

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21 January 2018

Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase

1 reference

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21 January 2018

Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase

1 reference

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21 January 2018

Engineering of peptide synthetases. Key role of the thioesterase-like domain for efficient production of recombinant peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Universal catalytic domain structure of AdoMet-dependent methyltransferases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Thin-layer chromatography of amino acids

1 reference

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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21 January 2018

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

WHAT IF: a molecular modeling and drug design program

1 reference

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21 January 2018

Errors in protein structures

1 reference

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21 January 2018

Crystal structure of catechol O-methyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Chemical and biological evolution of nucleotide-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Predictive motifs derived from cytosine methyltransferases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Mutational analysis of the N-methyltransferase domain of the multifunctional enzyme enniatin synthetase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Arrangement of catalytic sites in the multifunctional enzyme enniatin synthetase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Probing the S-adenosylmethionine-binding site of rat guanidinoacetate methyltransferase. Effect of site-directed mutagenesis of residues that are conserved across mammalian non-nucleic acid methyltransferases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209719200

21 January 2018

Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase

1 reference

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21 January 2018

Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins

1 reference

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21 January 2018

Role of linkers in communication between protein modules

1 reference

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21 January 2018

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

1 reference

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21 January 2018

Biomimetic catalysis of SN2 reactions through cation-.pi. interactions. The role of polarizability in catalysis

1 reference

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21 January 2018

Evidence for the Importance of Polarizability in Biomimetic Catalysis Involving Cyclophane Receptors.

1 reference

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21 January 2018

Acetylcholine binding by a synthetic receptor: implications for biological recognition

1 reference

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21 January 2018

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1 reference

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21 January 2018

Implications of a consensus recognition site for phosphatidylcholine separate from the active site in cobra venom phospholipases A2.

1 reference

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21 January 2018

Cation-pi bonding and amino-aromatic interactions in the biomolecular recognition of substituted ammonium ligands

1 reference

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21 January 2018

Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines

1 reference

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21 January 2018

The Swiss-3DImage collection and PDB-Browser on the World-Wide Web

1 reference

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21 January 2018

Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains

1 reference

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21 January 2018

Biochemical characterization of peptidyl carrier protein (PCP), the thiolation domain of multifunctional peptide synthetases

1 reference

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21 January 2018

Chain termination steps in nonribosomal peptide synthetase assembly lines: directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis

1 reference

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21 January 2018

Cell-free biosynthesis of new cyclosporins

1 reference

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21 January 2018

Identification of a tyrosine residue in rat guanidinoacetate methyltransferase that is photolabeled with S-adenosyl-L-methionine

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M209719200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12399454%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12399454%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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