(Q44203939)

English

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

scientific article published on 31 October 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 November 2017

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Alejandro Losada

5

object named as

Alejandro Losada

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Europe PubMed Central

PubMed publication ID

30 November 2017

author name string

Ana Cuadrado

1

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Europe PubMed Central

PubMed publication ID

30 November 2017

Luis F Garcia-Fernandez

2

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Europe PubMed Central

PubMed publication ID

30 November 2017

Laura Gonzalez

3

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Yajaira Suarez

4

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Europe PubMed Central

PubMed publication ID

30 November 2017

Victoria Alcaide

6

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Teresa Martinez

7

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Jose Maria Fernandez-Sousa

8

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Jose Maria Sanchez-Puelles

9

1 reference

Europe PubMed Central

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30 November 2017

Alberto Munoz

10

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30 November 2017

language of work or name

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publication date

31 October 2002

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Europe PubMed Central

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30 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

30 November 2017

278

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30 November 2017

1

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30 November 2017

241-250

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30 November 2017

Structure--activity relationships of the didemnins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Apoptosis in cancer therapy: crossing the threshold

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Tyrosine kinase inhibition: an approach to drug development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Autophosphorylation sites on the epidermal growth factor receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

The EGF receptor as central transducer of heterologous signalling systems

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Action of Myc in vivo - proliferation and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

ASK1 mediates apoptotic cell death induced by genotoxic stress.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

AP-1 in cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Polyamine contents of human breast cancer cells treated with the cytotoxic agents chlorpheniramine and dehydrodidemnin B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Lack of c-Jun activity increases survival to cisplatin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Epidermal growth factor receptor is modulated by redox through multiple mechanisms. Effects of reductants and H2O2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201010200

21 January 2018

Interleukin-1beta induction of mitogen-activated protein kinases in human mesangial cells. Role of oxidation

1 reference

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21 January 2018

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M201010200

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

release_ppgttatdzbdrdem4akxo6kidl4

1 reference

https://api.fatcat.wiki/v0/release/ppgttatdzbdrdem4akxo6kidl4

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

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