(Q44233686)

1 December 2017

title

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism (English)

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1 December 2017

Larisa Toulokhonova

1

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1 December 2017

William J Metzler

2

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1 December 2017

Mark R Witmer

3

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1 December 2017

Robert A Copeland

4

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1 December 2017

Jovita Marcinkeviciene

5

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1 December 2017

language of work or name

English

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publication date

27 November 2002

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Journal of Biological Chemistry

1 December 2017

published in

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1 December 2017

volume

278

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1 December 2017

issue

7

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1 December 2017

page(s)

4582-4589

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 December 2017

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Human immunodeficiency virus-1 protease. 2. Use of pH rate studies and solvent kinetic isotope effects to elucidate details of chemical mechanism

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Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers

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X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

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Substrate specificity of recombinant human renal renin: effect of histidine in the P2 subsite on pH dependence

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A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond

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Low-barrier hydrogen bonds and enzymic catalysis

21 January 2018

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Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism

21 January 2018

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Maintenance of blood pressure by the renin–angiotensin system in normal man

21 January 2018

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Solvent isotope effects on the onset of inhibition of porcine pepsin by pepstatin

21 January 2018

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Slow step after bond-breaking by porcine pepsin identified using solvent deuterium isotope effects

21 January 2018

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Conformational flexibility of the catalytic Asp dyad in HIV-1 protease: An ab initio study on the free enzyme

21 January 2018

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Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

21 January 2018

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Protonation-state dependence of hydrogen bond strengths and exchange rates in a serine protease catalytic triad: bovine chymotrypsinogen A

21 January 2018

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Hydrogen bonding in proteins as studied by amide hydrogen D/H fractionation factors: application to staphylococcal nuclease

21 January 2018

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Characterization of recombinant, soluble beta-secretase from an insect cell expression system.

21 January 2018

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Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

21 January 2018

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Kinetics of enzymes with iso-mechanisms: dead-end inhibition of fumarase and carbonic anhydrase II

21 January 2018

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Theoretical Investigation of the Relationship between Proton NMR Chemical Shift and Hydrogen Bond Strength

21 January 2018

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Kinetics of enzymes with iso-mechanisms: solvent isotope effects

21 January 2018

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Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M210471200

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1 December 2017

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