(Q44238580)

1 December 2017

title

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle (English)

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1 December 2017

main subject

transmembrane protein

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author

Marc Parmentier

9

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1 December 2017

1

Cédric Blanpain

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1 December 2017

Benjamin J Doranz

2

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1 December 2017

Antoine Bondue

3

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1 December 2017

Cédric Govaerts

4

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1 December 2017

Anne De Leener

5

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1 December 2017

Gilbert Vassart

6

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1 December 2017

Robert W Doms

7

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1 December 2017

Amanda Proudfoot

8

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1 December 2017

language of work or name

English

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publication date

3 December 2002

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Journal of Biological Chemistry

1 December 2017

published in

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1 December 2017

volume

278

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1 December 2017

issue

7

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1 December 2017

page(s)

5179-5187

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The biology of chemokines and their receptors

1 December 2017

cites work

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Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication

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LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity

21 January 2018

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Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

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Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages

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Importance of basic residues and quaternary structure in the function of MIP-1 beta: CCR5 binding and cell surface sugar interactions

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Structural and functional analysis of the RANTES-glycosaminoglycans interactions

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Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2.

21 January 2018

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Identification of receptor binding and activation determinants in the N-terminal and N-loop regions of the CC chemokine eotaxin

21 January 2018

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21 January 2018

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The second extracellular loop of CCR5 is the major determinant of ligand specificity.

21 January 2018

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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

21 January 2018

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Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

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Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

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21 January 2018

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The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

21 January 2018

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Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

21 January 2018

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Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.

21 January 2018

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Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry

21 January 2018

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Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor

21 January 2018

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Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor.

21 January 2018

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Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

21 January 2018

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CC chemokine receptor 5 and renal-transplant survival

21 January 2018

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CC chemokine MIP-1 beta can function as a monomer and depends on Phe13 for receptor binding

21 January 2018

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A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M205684200

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1 December 2017

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