(Q44264338)

1 December 2017

title

Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation (English)

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1 December 2017

Arthur J L Cooper

1

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1 December 2017

Sam A Bruschi

series ordinal

2

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1 December 2017

Myra Conway

series ordinal

3

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1 December 2017

Susan M Hutson

series ordinal

4

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1 December 2017

language of work or name

English

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publication date

1 January 2003

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1 December 2017

published in

Biochemical Pharmacology

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1 December 2017

volume

65

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1 December 2017

issue

2

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1 December 2017

page(s)

181-192

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Refinement and Comparisons of the Crystal Structures of Pig Cytosolic Aspartate Aminotransferase and Its Complex with 2-Methylaspartate

1 December 2017

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Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity

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Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination

7 January 2021

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Three-dimensional structure of 4-amino-4-deoxychorismate lyase from Escherichia coli

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Stereochemistry of the transamination reaction catalyzed by aminodeoxychorismate lyase from Escherichia coli: close relationship between fold type and stereochemistry.

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Structure and function of branched chain aminotransferases

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Interrelationships of leucine and glutamate metabolism in cultured astrocytes

7 January 2021

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Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells

7 January 2021

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Astrocyte leucine metabolism: significance of branched-chain amino acid transamination

7 January 2021

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Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture

7 January 2021

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Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism.

7 January 2021

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Distribution of key enzymes of branched-chain amino acid metabolism in glial and neuronal cells in culture

7 January 2021

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Function of leucine in excitatory neurotransmitter metabolism in the central nervous system

7 January 2021

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Nitrogen shuttling between neurons and glial cells during glutamate synthesis

7 January 2021

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beta-elimination of beta-halo substrates by D-amino acid transaminase associated with inactivation of the enzyme. Trapping of a key intermediate in the reaction

7 January 2021

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The reaction of L-serine O-sulfate with aspartate aminotransferase.

7 January 2021

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Labeling of the active site of cytoplasmic aspartate aminotransferase by β-chloro-L-alanine

7 January 2021

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The C-S lysis of L-cysteine conjugates by aspartate and alanine aminotransferase enzymes

7 January 2021

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Novel sources of mammalian C-S lyase activity

7 January 2021

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Rationalisation of the C-S lyase activity of aspartate amino transferase.

7 January 2021

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Cysteine conjugate beta-lyase activity of amino acid decarboxylases

7 January 2021

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Inactivation of brain and kidney aspartate aminotransferases by S-(1,2,-dichlorovinyl)-L-cysteine and by S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine

7 January 2021

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Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions

7 January 2021

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Modes of action of trichloroethylene for kidney tumorigenesis

7 January 2021

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Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate

7 January 2021

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Renal cell carcinomas in trichloroethene (TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene

7 January 2021

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Trichloroethylene and cancer: epidemiologic evidence.

7 January 2021

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The metabolism and nephrotoxicity of tetrafluoroethylene in the rat.

7 January 2021

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Perchloroethylene-induced rat kidney tumors: an investigation of the mechanisms involved and their relevance to humans

7 January 2021

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Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes

7 January 2021

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Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.

7 January 2021

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Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells

7 January 2021

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Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine

7 January 2021

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Formation of difluorothionoacetyl-protein adducts by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine metabolites: nucleophilic catalysis of stable lysyl adduct formation by histidine and tyrosine

7 January 2021

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In vivo detection and characterization of protein adducts resulting from bioactivation of haloethene cysteine S-conjugates by 19F NMR: chlorotrifluoroethene and tetrafluoroethene

7 January 2021

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Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death

7 January 2021

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Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine

7 January 2021

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Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine

7 January 2021

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Bioactivation of xenobiotics by formation of toxic glutathione conjugates

7 January 2021

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Glutathione-dependent bioactivation of haloalkenes

7 January 2021

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Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism

7 January 2021

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Co-purification of mitochondrial HSP70 and mature protein disulfide isomerase with a functional rat kidney high-M(r) cysteine S-conjugate beta-lyase

7 January 2021

1 reference

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Overexpression and characterization of the human mitochondrial and cytosolic branched-chain aminotransferases

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901513-7

Mammalian branched-chain aminotransferases

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901513-7

A continuous 96-well plate spectrophotometric assay for branched-chain amino acid aminotransferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901513-7

KINETIC STUDIES OF GLUTAMIC OXALOACETIC TRANSAMINASE ISOZYMES.

7 January 2021

1 reference

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A novel reaction of the coenzyme of glutamate decarboxylase with L-serine O-sulfate

7 January 2021

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Chemistry of the inactivation of cytosolic aspartate aminotransferase by serine O-sulfate

7 January 2021

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A molecular model of human branched-chain amino acid metabolism

7 January 2021

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Formation of dichloroacetylene from trichloroethylene in the presence of alkaline material--possible cause of intoxication after abundant use of chloroethylene-containing solvents

7 January 2021

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Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation

7 January 2021

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Polyneuritis cranialis associated with industrial trichloroethylene poisoning

7 January 2021

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Brain uptake of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene

7 January 2021

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10.1016/S0006-2952(02)01513-7

7 January 2021

Identifiers

DOI

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1 December 2017

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