(Q44280046)

1 December 2017

title

The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity (English)

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1 December 2017

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2

Ana Denicola

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1 December 2017

Leonor Thomson

1

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1 December 2017

Rafael Radi

series ordinal

3

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1 December 2017

language of work or name

English

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publication date

1 April 2003

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Archives of Biochemistry and Biophysics

1 December 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

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1 December 2017

volume

412

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1 December 2017

issue

1

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1 December 2017

page(s)

55-64

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Peroxynitrite formation from macrophage-derived nitric oxide

1 December 2017

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Peroxynitrite inactivates thiol-containing enzymes of Trypanosoma cruzi energetic metabolism and inhibits cell respiration

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The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

7 January 2021

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TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

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Evidence for a trypanothione-dependent peroxidase system in Trypanosoma cruzi

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His-tagged tryparedoxin peroxidase of Trypanosoma cruzi as a tool for drug screening

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Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi

7 January 2021

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7 January 2021

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7 January 2021

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Spin-trapping studies of peroxynitrite decomposition and of 3-morpholinosydnonimine N-ethylcarbamide autooxidation: direct evidence for metal-independent formation of free radical intermediates

7 January 2021

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Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radical

7 January 2021

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Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies

7 January 2021

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Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols--a high resolution ESR spin-trapping study at Q-band (35 GHz)

7 January 2021

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Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Diffusion of peroxynitrite across erythrocyte membranes

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols

7 January 2021

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Kinetic analysis of reactivity of peroxynitrite with biomolecules

7 January 2021

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Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation

7 January 2021

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Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0003-9861(02)00745-2

1 reference

1 December 2017

1 reference