(Q44323344)

2 December 2017

title

Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway (English)

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2 December 2017

4

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2 December 2017

Karine Merienne

1

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2 December 2017

Dominique Helmlinger

series ordinal

2

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2 December 2017

Gordon R Perkin

series ordinal

3

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2 December 2017

Yvon Trottier

series ordinal

5

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2 December 2017

language of work or name

English

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publication date

21 February 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

issue

19

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2 December 2017

page(s)

16957-16967

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Glutamine repeats and neurodegeneration

2 December 2017

cites work

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

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Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

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Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

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Histone deacetylase inhibitors reduce polyglutamine toxicity

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72.

21 January 2018

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

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Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

21 January 2018

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

21 January 2018

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The JNK phosphatase M3/6 is inhibited by protein-damaging stress

21 January 2018

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Differential effects of stress stimuli on a JNK-inactivating phosphatase

21 January 2018

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Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

21 January 2018

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

21 January 2018

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AP-1 as a regulator of cell life and death

21 January 2018

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

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Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

21 January 2018

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

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Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

21 January 2018

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Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice

21 January 2018

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Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.

21 January 2018

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A cellular model that recapitulates major pathogenic steps of Huntington's disease

21 January 2018

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

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Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice

21 January 2018

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Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

21 January 2018

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Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

21 January 2018

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Signal transduction by the JNK group of MAP kinases

21 January 2018

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hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase

21 January 2018

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Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

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From the cradle to the grave: molecular chaperones that may choose between folding and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212049200

21 January 2018

Identifiers

DOI

10.1074/JBC.M212049200

1 reference

2 December 2017

1 reference