(Q44345837)

2 December 2017

title

Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery (English)

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G protein-coupled receptor

2 December 2017

main subject

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opioid

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heroin

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ChEBI release 2020-05-28

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1

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2 December 2017

3

R J Lefkowitz

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2 December 2017

4

M G Caron

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2 December 2017

L A Dykstra

2

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2 December 2017

L S Barak

series ordinal

5

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2 December 2017

publication date

1 July 2004

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2 December 2017

published in

Molecular Pharmacology

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2 December 2017

volume

66

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2 December 2017

issue

1

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2 December 2017

page(s)

106-112

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Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment

2 December 2017

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Morphine-activated opioid receptors elude desensitization by beta-arrestin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Morphine activates opioid receptors without causing their rapid internalization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Evidence from opiate binding studies that heroin acts through its metabolites

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Effects of chronic morphine administration on mu opioid receptor-stimulated [35S]GTPgammaS autoradiography in rat brain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Selective regulation of endogenous G protein-coupled receptors by arrestins in HEK293 cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

The effect of intrinsic efficacy on opioid tolerance

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Opioids: first lessons from knockout mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Enhanced morphine analgesia in mice lacking beta-arrestin 2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

mu Opioid receptor-mediated G-protein activation by heroin metabolites: evidence for greater efficacy of 6-monoacetylmorphine compared with morphine

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

beta-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Tolerance to mu-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5'-O-(3-[35S]-thio)triphosphate binding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

mu-Opioid receptor downregulation contributes to opioid tolerance in vivo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1124/MOL.66.1.106

Identifiers

DOI

10.1124/MOL.66.1.106

1 reference

2 December 2017

1 reference