(Q44388715)

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Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response

scientific article published on 2 April 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 December 2017

Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

1 reference

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author name string

Hector Lucero

1

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Darren Gae

2

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Guillermo E Taccioli

3

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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publication date

2 April 2003

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Europe PubMed Central

PubMed publication ID

2 December 2017

number of pages

8

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

2 December 2017

278

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Europe PubMed Central

PubMed publication ID

2 December 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

22136-22143

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

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Ku, a DNA repair protein with multiple cellular functions?

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Ku binds telomeric DNA in vitro

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Ku acts in a unique way at the mammalian telomere to prevent end joining

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Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

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The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks

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Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

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Expression, localization and functional interactions of Ku70 subunit of DNA-PK in peripheral lymphocytes and Nalm-19 cells after irradiation

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Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase

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The Ku-like protein from Saccharomyces cerevisiae is required in vitro for the assembly of a stable multiprotein complex at a eukaryotic origin of replication

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Ionizing radiation-induced MEK and Erk activation does not enhance survival of irradiated human squamous carcinoma cells

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The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

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Ionizing radiation stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor and ERBB-3, and changes of intracellular calcium in A431 human squamous carcinoma cells

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Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells.Miko

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Signal transduction and cellular radiation responses

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Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation

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Signal transduction of stress via ceramide

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Functions of lipid rafts in biological membranes

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Sphingolipid signalling domains floating on rafts or buried in caves?

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Signal transduction via CD44: role of plasma membrane microdomains

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Membrane rafts and signaling by the multichain immune recognition receptors

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Lipid rafts and signal transduction

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Ara-C- and daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts

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Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane.

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Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

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Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini

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Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

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Molecular and biochemical characterization of xrs mutants defective in Ku80.

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The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

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The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

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HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae.

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Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

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Hydrogen peroxide as second messenger in lymphocyte activation

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Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

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Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

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DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D

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The nuclear autoimmune antigen Ku is also present on the cell surface

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Cell surface expression of the 70-kD component of Ku, a DNA-binding nuclear autoantigen

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PDZ domains: structural modules for protein complex assembly

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Interaction between DNA-dependent protein kinase and a novel protein, KIP

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Signaling pathways leading to nuclear factor-kappa B activation

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Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast

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Activation of Raf by ionizing radiation

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Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated abl kinase is an ATM-dependent process

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Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation.

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Defective radiation signal transduction in ataxia-telangiectasia cells

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DNA-PKcs-OBA/Ku associate in the absence of DNA, as revealed by two-dimensional capillary gel electromobility shift assay

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Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells

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Identifiers

10.1074/JBC.M301579200

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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