(Q44403627)

English

Influence of Lipophilicity on the Interactions ofN-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6

scientific article published on May 1, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 December 2017

Influence of Lipophilicity on the Interactions ofN-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6 (English)

reason for preferred rank

most precise value

1 reference

10.1124/DMD.31.5.596

https://api.crossref.org/works/10.1124/DMD.31.5.596

24 December 2023

Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695348

24 December 2023

1 reference

ChEBI release 2020-05-28

pharmaceutical science

1 reference

10.1124/DMD.31.5.596

https://api.crossref.org/works/10.1124/DMD.31.5.596

24 December 2023

1 reference

10.1124/DMD.31.5.596

https://api.crossref.org/works/10.1124/DMD.31.5.596

24 December 2023

author name string

Sue Zhou

2

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Amit S. Kalgutkar

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695348

24 December 2023

Odette A. Fahmi

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695348

24 December 2023

Timothy J. Taylor

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12695348

24 December 2023

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12695348

24 December 2023

publication date

1 May 2003

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

full work available at URL

https://syndication.highwire.org/content/doi/10.1124/dmd.31.5.596

1 reference

10.1124/DMD.31.5.596

https://api.crossref.org/works/10.1124/DMD.31.5.596

24 December 2023

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

31

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

596-605

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Quantitative structure-metabolism relationship analyses of MAO-mediated toxication of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and analogues

1

1 reference

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24 December 2023

Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives

2

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24 December 2023

Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

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A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

5

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24 December 2023

The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.

6

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24 December 2023

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

7

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24 December 2023

The role of lipophilicity in the inhibition of polymorphic cytochrome P450IID6 oxidation by beta-blocking agents in vitro

9

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24 December 2023

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

10

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24 December 2023

Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity

11

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24 December 2023

Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors

13

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24 December 2023

Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors

14

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24 December 2023

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

15

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24 December 2023

Rat liver microsomal enzyme catalyzed oxidation of 4-phenyl-trans-1-(2-phenylcyclopropyl)-1,2,3,6-tetrahydropyridine

16

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24 December 2023

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

17

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24 December 2023

Grapefruit juice substantially increases plasma concentrations of buspirone

18

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24 December 2023

Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6.

19

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24 December 2023

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

20

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24 December 2023

The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds

22

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24 December 2023

Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis

23

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24 December 2023

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

24

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24 December 2023

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

25

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24 December 2023

Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

26

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24 December 2023

Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol

27

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24 December 2023

Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains

29

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24 December 2023

Potent inhibition of CYP2D6 by haloperidol metabolites: stereoselective inhibition by reduced haloperidol

30

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24 December 2023

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

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24 December 2023

Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase).

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24 December 2023

Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurotoxic pyridinium metabolites by human liver microsomes

34

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24 December 2023

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

36

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24 December 2023

Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects

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24 December 2023

Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

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Interactions of amphetamine analogs with human liver CYP2D6

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24 December 2023

Identifiers

10.1124/DMD.31.5.596

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

ResearchGate publication ID

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