(Q44451243)

3 December 2017

title

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines (English)

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3 December 2017

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Backus HH

1

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3 December 2017

Wouters D

2

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3 December 2017

Ferreira CG

3

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3 December 2017

van Houten VM

4

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3 December 2017

Brakenhoff RH

5

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3 December 2017

Pinedo HM

6

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3 December 2017

Peters GJ

7

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3 December 2017

publication date

1 June 2003

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European Journal of Cancer

3 December 2017

published in

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3 December 2017

volume

39

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3 December 2017

issue

9

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3 December 2017

page(s)

1310-1317

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The catalytic mechanism and structure of thymidylate synthase

3 December 2017

cites work

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AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies

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7 January 2021

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed

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7 January 2021

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates

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7 January 2021

5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins

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7 January 2021

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7 January 2021

Chemotherapy-induced apoptosis

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7 January 2021

Induction of apoptosis by cancer chemotherapy.

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Apoptosis and drug response

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7 January 2021

Thymineless death in colon carcinoma cells is mediated via fas signaling

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7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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7 January 2021

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

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7 January 2021

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

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7 January 2021

A simple p53 functional assay for screening cell lines, blood, and tumors

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7 January 2021

Identification of p53 gene mutations in bladder cancers and urine samples

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7 January 2021

Molecular diagnosis of head and neck cancer.

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7 January 2021

Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing

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7 January 2021

Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism

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7 January 2021

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients

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7 January 2021

Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays

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7 January 2021

Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

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7 January 2021

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

1 reference

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7 January 2021

Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2803%2900204-1

7 January 2021

10.1016/S0959-8049(03)00204-1

Identifiers

DOI

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3 December 2017

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