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A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity

scientific article published in May 2003

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Europe PubMed Central

3 December 2017

A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity (English)

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Europe PubMed Central

3 December 2017

2

David Julius

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stated in

Europe PubMed Central

3 December 2017

Elizabeth D Prescott

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Europe PubMed Central

PubMed ID

12764195

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3 December 2017

language of work or name

English

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1 May 2003

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Europe PubMed Central

3 December 2017

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Europe PubMed Central

3 December 2017

300

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3 December 2017

1284-1288

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Europe PubMed Central

3 December 2017

5623

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Europe PubMed Central

3 December 2017

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

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Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization.

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Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

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TRPV3 is a calcium-permeable temperature-sensitive cation channel.

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

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Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia

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Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.

1 reference

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Induction of vanilloid receptor channel activity by protein kinase C

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Regulation of TRP channels via lipid second messengers.

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Impaired nociception and pain sensation in mice lacking the capsaicin receptor

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The TRPM7 channel is inactivated by PIP(2) hydrolysis

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TRPV3 is a temperature-sensitive vanilloid receptor-like protein.

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A heat-sensitive TRP channel expressed in keratinocytes

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The cloned capsaicin receptor integrates multiple pain-producing stimuli

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Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues

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Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

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Identifiers

DOI

10.1126/SCIENCE.1083646

1 reference

stated in

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

PubMed ID

12764195

retrieved

3 December 2017

(Q44452050)

A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity

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