(Q44462230)

English

The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane dom

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 December 2017

The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane dom (English)

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Europe PubMed Central

PubMed publication ID

3 December 2017

transmembrane protein

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author name string

Liwen Xu

1

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Europe PubMed Central

PubMed publication ID

3 December 2017

Robert D Simoni

2

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Europe PubMed Central

PubMed publication ID

3 December 2017

language of work or name

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publication date

1 June 2003

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Europe PubMed Central

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3 December 2017

number of pages

12

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based on heuristic

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Archives of Biochemistry and Biophysics

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Europe PubMed Central

PubMed publication ID

3 December 2017

414

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Europe PubMed Central

PubMed publication ID

3 December 2017

2

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Europe PubMed Central

PubMed publication ID

3 December 2017

232-243

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Europe PubMed Central

PubMed publication ID

3 December 2017

Regulation of the mevalonate pathway

1 reference

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Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo

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Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase

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Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

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Oligomerization state influences the degradation rate of 3-hydroxy-3-methylglutaryl-CoA reductase

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Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution

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The structure of the catalytic portion of human HMG-CoA reductase

1 reference

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Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

1 reference

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7 January 2021

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

1 reference

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Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

1 reference

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Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

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Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

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The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport

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Transport-Dependent Proteolysis of SREBP

1 reference

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Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

1 reference

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Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

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Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

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Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

1 reference

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7 January 2021

Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

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7 January 2021

Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.

1 reference

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7 January 2021

Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease.

1 reference

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Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum

1 reference

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7 January 2021

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

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7 January 2021

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

1 reference

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The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

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7 January 2021

Identifiers

10.1016/S0003-9861(03)00168-1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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