(Q44508741)

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Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways (English)

1 reference

Europe PubMed Central

3 December 2017

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prostate cancer

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author name string

Jae-Il Park

1

1 reference

Europe PubMed Central

3 December 2017

Min-Goo Lee

2

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Europe PubMed Central

3 December 2017

Kyucheol Cho

3

1 reference

Europe PubMed Central

3 December 2017

Bum-Joon Park

4

1 reference

Europe PubMed Central

3 December 2017

Kwon-Seok Chae

5

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Europe PubMed Central

3 December 2017

Do-Sun Byun

6

1 reference

Europe PubMed Central

3 December 2017

Byung-Kyu Ryu

7

1 reference

Europe PubMed Central

3 December 2017

Yong-Keun Park

8

1 reference

Europe PubMed Central

3 December 2017

Sung-Gil Chi

9

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Europe PubMed Central

3 December 2017

language of work or name

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publication date

1 July 2003

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Europe PubMed Central

3 December 2017

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Europe PubMed Central

3 December 2017

22

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Europe PubMed Central

3 December 2017

4314-4332

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Europe PubMed Central

3 December 2017

28

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Europe PubMed Central

3 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206478

0 references

Regulation of spontaneous and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines.

1 reference

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21 January 2018

Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway

1 reference

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21 January 2018

TGF beta in prostate cancer: a growth inhibitor that can enhance tumorigenicity

1 reference

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21 January 2018

The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

1 reference

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21 January 2018

HuR and mRNA stability

1 reference

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21 January 2018

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

1 reference

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21 January 2018

Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

1 reference

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21 January 2018

AU-rich elements: characterization and importance in mRNA degradation

1 reference

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21 January 2018

A transcriptional partner for MAD proteins in TGF-beta signalling

1 reference

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21 January 2018

Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines

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21 January 2018

Interleukin 6 induces the expression of vascular endothelial growth factor

1 reference

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21 January 2018

p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system

1 reference

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21 January 2018

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

1 reference

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21 January 2018

Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells.

1 reference

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21 January 2018

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

1 reference

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21 January 2018

Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts.

1 reference

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21 January 2018

Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production

1 reference

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21 January 2018

Interleukin-6 (IL-6) functions as an autocrine growth factor in cervical carcinomas in vitro

1 reference

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21 January 2018

Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2.

1 reference

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21 January 2018

Transforming growth factor-beta increases interleukin-6 transcripts in osteoblasts

1 reference

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21 January 2018

Interleukin-6 is an autocrine growth factor in human prostate cancer.

1 reference

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21 January 2018

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

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21 January 2018

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

1 reference

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21 January 2018

Interleukin-6 and its receptor: a paradigm for cytokines

1 reference

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21 January 2018

Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB.

1 reference

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21 January 2018

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

1 reference

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21 January 2018

Smads bind directly to the Jun family of AP-1 transcription factors

1 reference

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21 January 2018

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

1 reference

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21 January 2018

Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein

1 reference

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21 January 2018

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

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21 January 2018

The transforming growth factor-beta family

1 reference

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21 January 2018

Effect of transforming growth factor-beta1 on interleukin-6 secretion in human myoblasts.

1 reference

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21 January 2018

c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells

1 reference

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21 January 2018

Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways

1 reference

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21 January 2018

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

1 reference

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21 January 2018

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

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21 January 2018

Interleukin-6 and epidermal growth factor promote anchorage-independent growth of immortalized human prostatic epithelial cells treated with N-methyl-N-nitrosourea

1 reference

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21 January 2018

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

1 reference

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21 January 2018

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

1 reference

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21 January 2018

Control of messenger RNA stability in higher eukaryotes

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Novel regulation of type IV collagenase (matrix metalloproteinase-9 and -2) activities by transforming growth factor-beta1 in human prostate cancer cell lines

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Transcriptional coactivators potentiating AP-1 function in bone.

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21 January 2018

Interleukin-6: a candidate mediator of human prostate cancer morbidity

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21 January 2018

IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes

1 reference

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21 January 2018

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

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21 January 2018

Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase

1 reference

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21 January 2018

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

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21 January 2018

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

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21 January 2018

Characterization of human FAST-1, a TGF beta and activin signal transducer

1 reference

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21 January 2018

Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer

1 reference

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Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

1 reference

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7 January 2021

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Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta 1-induced IL-6 expression

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Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase

1 reference

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Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.

1 reference

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7 January 2021

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Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade

1 reference

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Requirement of transforming growth factor-beta (TGF-beta) type II receptor for TGF-beta-induced proliferation and growth inhibition

1 reference

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7 January 2021

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Identifiers

10.1038/SJ.ONC.1206478

1 reference

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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