(Q44509795)

3 December 2017

title

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis (English)

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3 December 2017

Xianglin Wu

1

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3 December 2017

Junjie Chen

series ordinal

2

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3 December 2017

language of work or name

English

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publication date

9 July 2003

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Journal of Biological Chemistry

3 December 2017

published in

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3 December 2017

volume

278

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3 December 2017

issue

38

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3 December 2017

page(s)

36163-36168

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The DNA damage response: putting checkpoints in perspective

3 December 2017

cites work

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

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21 January 2018

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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21 January 2018

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Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

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Caffeine inhibits the checkpoint kinase ATM

21 January 2018

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

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Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis

21 January 2018

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Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

21 January 2018

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Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

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21 January 2018

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

21 January 2018

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The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

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21 January 2018

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Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

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21 January 2018

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

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Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303795200

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3 December 2017

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