(Q44519240)

3 December 2017

title

Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer (English)

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3 December 2017

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Kimihiko Ohtsuka

1

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3 December 2017

Shoichi Inoue

2

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3 December 2017

Masayo Kameyama

3

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3 December 2017

Akio Kanetoshi

4

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3 December 2017

Toru Fujimoto

5

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3 December 2017

Kazuo Takaoka

6

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3 December 2017

Yoshikazu Araya

7

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3 December 2017

Akira Shida

8

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3 December 2017

publication date

1 August 2003

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3 December 2017

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3 December 2017

volume

41

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3 December 2017

issue

2

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3 December 2017

page(s)

187-198

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A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer

3 December 2017

cites work

1 reference

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7 January 2021

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer

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7 January 2021

Present and future treatment of advanced non-small cell lung cancer

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7 January 2021

Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase

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https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

45 Carboxylesterases-amidases

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7 January 2021

Establishment and characterization of human gastric and colonic xenograft lines resistant to CPT-11 (a new derivative of camptothecin).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Metabolism of Irinotecan to SN-38 in a Tissue-Isolated Tumor Model

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Glucuronidation of SN-38, the Active Metabolite of Irinotecan, by Human Hepatic Microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

CPT-11 converting carboxylesterase and topoisomerase activities in tumour and normal colon and liver tissues

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7 January 2021

Characterization of CPT-11 converting carboxylesterase activity in colon tumor and normal tissues: comparison with p-nitro-phenylacetate converting carboxylesterase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

In vitro confirmation of newly established lung cancer cell lines using flow cytometry and multicellular tumor spheroids

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug

1 reference

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7 January 2021

The role of glucuronidation in 7-ethyl-10-hydroxycamptothecin resistance in vitro

1 reference

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7 January 2021

The induction of hepatic microsomal UDP-glucuronosyltransferase by the methylsulfonyl metabolites of polychlorinated biphenyl congeners in rats

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7 January 2021

CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants

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7 January 2021

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

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7 January 2021

Quantitative analysis of DNA topoisomerase I activity in human and rat glioma: characterization and mechanism of resistance to antitopoisomerase chemical, camptothecin-11.

1 reference

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7 January 2021

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Polymorphisms of UDP-glucuronosyltransferase and pharmacokinetics of irinotecan.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Histochemical and immunohistochemical detection of putative preneoplastic liver foci in women after long-term use of oral contraceptives.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

Effective irinotecan (CPT-11)-containing liposomes: intraliposomal conversion to the active metabolite SN-38.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-5002%2803%2900223-X

7 January 2021

10.1016/S0169-5002(03)00223-X

Identifiers

DOI

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3 December 2017

1 reference