(Q44524591)

3 December 2017

title

Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance (English)

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3 December 2017

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2

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6

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8

R A DeFronzo

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1

E Ferrannini

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3 December 2017

Y Miyazaki

3

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M Matsuda

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4

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3 December 2017

M Pettiti

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5

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A Mari

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7

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3 December 2017

publication date

23 July 2003

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volume

46

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3 December 2017

issue

9

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3 December 2017

page(s)

1211-1219

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The kinetics of insulin in man. II. Role of the liver

3 December 2017

cites work

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12 December 2020

Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat

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12 December 2020

Disturbances in beta-cell function in impaired fasting glycemia.

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12 December 2020

Basal hepatic glucose production is regulated by the portal vein insulin concentration.

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12 December 2020

Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes

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12 December 2020

Quantitative Study on the Potentiating Effect of Arginine on Glucose-induced Insulin Response in Healthy, Prediabetic, and Diabetic Subjects

1 reference

12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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12 December 2020

The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity.

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12 December 2020

The disposal of an oral glucose load in healthy subjects. A quantitative study

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12 December 2020

The disposal of an oral glucose load in patients with non-insulin-dependent diabetes

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12 December 2020

Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects

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12 December 2020

Peripheral and hepatic insulin sensitivity in subjects with impaired glucose tolerance

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12 December 2020

Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.

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12 December 2020

Measurement of size and turnover rate of body glucose pool by the isotope dilution method

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12 December 2020

Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects.

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12 December 2020

Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.

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12 December 2020

Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus.

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12 December 2020

The relationship of insulin response to a glucose stimulus over a wide range of glucose tolerance

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12 December 2020

Further studies on healthy subjects with low and high insulin response to glucose infusion

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12 December 2020

Failure to adequately adapt reduced insulin sensitivity with increased insulin secretion in women with impaired glucose tolerance.

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12 December 2020

Assessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion.

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12 December 2020

Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance

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12 December 2020

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance

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12 December 2020

Influences of glucose loading and of injected insulin on hepatic glucose output

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12 December 2020

Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women

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12 December 2020

Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR).

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12 December 2020

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

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12 December 2020

Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance.

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12 December 2020

Insulin secretion and insulin sensitivity in people with impaired glucose tolerance.

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12 December 2020

Threshold secretory mechanism: a model of derivative element in biological control.

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12 December 2020

Estimation of beta-cell sensitivity from intravenous glucose tolerance test C-peptide data. Knowledge of the kinetics avoids errors in modeling the secretion

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12 December 2020

Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance

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12 December 2020

Potentiation of glucose-induced insulin secretion in the perfused rat pancreas by porcine GIP (gastric inhibitory polypeptide), bovine GIP, and bovine GIP(1-39)

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12 December 2020

Differential roles of splanchnic and peripheral tissues in the pathogenesis of impaired glucose tolerance

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12 December 2020

Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation

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12 December 2020

Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance

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12 December 2020

Potentiation of insulin release by glucose in man. I. Quantitative analysis of the enhancement of glucose-induced insulin secretion by pretreatment with glucose in normal subjects

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12 December 2020

Effect of GIP and GLP-1 antagonists on insulin release in the rat

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12 December 2020

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects

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12 December 2020

High and low insulin responders: relations to oral glucose tolerance, insulin secretion and physical fitness

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12 December 2020

10.1007/S00125-003-1169-6

Identifiers

DOI

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3 December 2017

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