(Q44539037)

English

Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2alpha-methyl introduction on antagonistic activity

scientific article published in August 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2alpha-methyl introduction on antagonistic activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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author name string

Toshie Fujishima

1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Yoshinori Kojima

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Isao Azumaya

3

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Atsushi Kittaka

4

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Hiroaki Takayama

5

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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publication date

1 August 2003

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Bioorganic & Medicinal Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

17

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

3621-3631

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

The steroid and thyroid hormone receptor superfamily

1 reference

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

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Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

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Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog

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Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators

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Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

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Molecular basis of the selective activity of vitamin D analogues

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Critical role of helix 12 of the vitamin D(3) receptor for the partial agonism of carboxylic ester antagonists

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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

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Rational discovery of novel nuclear hormone receptor antagonists

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Synthetic studies of vitamin D3 analogues. VIII. Synthesis of 22-oxavitamin D3 analogues

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A Novel Vitamin D3Analog, 22-Oxa-1, 25- Dihydroxyvitamin D3, Inhibits the Growth of Human Breast Cancerin Vitroandin Vivowithout Causing Hypercalcemia*

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20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

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Differentiation-related pathways of 1 alpha,25-dihydroxycholecalciferol metabolism in human colon adenocarcinoma-derived Caco-2 cells: production of 1 alpha,25-dihydroxy-3epi-cholecalciferol

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A novel and practical route to A-ring enyne synthon for 1 alpha,25-dihydroxyvitamin D3 analogs: synthesis of A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D2 and 3-methyl-1,25-dihydroxyvitamin D3

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Synthesis, biological evaluation, and conformational analysis of A-ring diastereomers of 2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: unique activity profiles depending on the stereochemistry of the A-ring and at C-20.

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Efficient synthesis and biological evaluation of all A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 and its 20-epimer

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Novel ring A stereoisomers of 2-methyl-1alpha,25-dihydroxyvitamin D(3) and 2-methyl-20-epi-1alpha,25-dihydroxyvitamin D(3): transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells

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Highly potent cell differentiation-inducing analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D3 with side-chain modifications

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Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D(3) and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor

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Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity

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Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators

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Carboxylic ester antagonists of 1alpha,25-dihydroxyvitamin D(3) show cell-specific actions.

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Structure activity relationship of carboxylic ester antagonists of the vitamin D(3) receptor

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Antagonistic action of novel 1alpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1alpha,25-dihydroxyvitamin D3

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1,25-Dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease

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Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

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Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts

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Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease

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New metabolic pathway of (24R)-24,25-dihydroxyvitamin D3: epimerization of the 3-hydroxy group

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Tissue specific metabolism of 1alpha,25-dihydroxy-20-epi-vitamin D3 into new metabolites with significant biological activity: studies in rat osteosarcoma cells (UMR 106 and ROS 17/2.8).

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Metabolism of 2-methyl analogs of 1alpha,25-dihydroxyvitamin D3 in rat osteosarcoma cells (UMR 106).

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Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3.

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Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3

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Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide

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Identifiers

10.1016/S0968-0896(03)00371-7

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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