(Q44539072)

3 December 2017

title

Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065. (English)

1 reference

3 December 2017

Jay P Parrish

1

1 reference

3 December 2017

David B Kastrinsky

2

1 reference

3 December 2017

Frederic Stauffer

3

1 reference

3 December 2017

Michael P Hedrick

4

1 reference

3 December 2017

Inkyu Hwang

5

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3 December 2017

Dale L Boger

6

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3 December 2017

language of work or name

English

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publication date

1 August 2003

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Bioorganic & Medicinal Chemistry

3 December 2017

published in

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3 December 2017

volume

11

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3 December 2017

issue

17

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3 December 2017

page(s)

3815-3838

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Duocarmycin A, a new antitumor antibiotic from Streptomyces.

3 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Duocarmycins, potent antitumor antibiotics produced by Streptomyces sp. structures and chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

CC-1065 and the Duocarmycins: Synthetic Studies

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Sequence selectivity of DNA covalent modification

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Mechanisms of in situ activation for DNA-targeting antitumor agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Selective metal cation activation of a DNA alkylating agent: synthesis and evaluation of methyl 1,2,9, 9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI).

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivit

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysi

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

The structural basis for in situ activation of DNA alkylation by duocarmycin SA

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

CC-1065 CBI analogs: an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

CC-1065/duocarmycin and bleomycin A2 hybrid agents: lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Are the Duocarmycin and CC-1065 DNA Alkylation Reactions Acid-Catalyzed? Solvolysis pH-Rate Profiles Suggest They Are Not.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Recent developments in sequence selective minor groove DNA effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

DNA minor groove alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

Synthese von ?-Azidozimts�ureestern

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900194-9

7 January 2021

10.1016/S0968-0896(03)00194-9

Identifiers

DOI

1 reference

3 December 2017

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