(Q44568518)

English

Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates

scientific article published in August 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

0 references

author name string

Rohtash Kumar

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

J William Lown

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

publication date

1 August 2003

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Organic and Biomolecular Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

15

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

2630-2647

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

DNA and associated targets for drug design

1 reference

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21 January 2018

Sequence selectivity of DNA covalent modification

1 reference

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21 January 2018

Mode of action of saframycin antitumor antibiotics: sequence selectivities in the covalent binding of saframycins A and S to deoxyribonucleic acid

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Nonintercalating DNA-binding ligands: specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material

1 reference

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21 January 2018

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

1 reference

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21 January 2018

Concerted DNA recognition and novel site-specific alkylation by duocarmycin A with distamycin A.

1 reference

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21 January 2018

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065.

1 reference

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21 January 2018

Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit.

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Design of sequence-specific DNA-binding molecules

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Molecular struggle for transcriptional control

1 reference

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21 January 2018

Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

CC-1065 functional analogues possessing different electron-withdrawing substituents and leaving groups: synthesis, kinetics, and sequence specificity of reaction with DNA and biological evaluation

1 reference

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21 January 2018

Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice

1 reference

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21 January 2018

Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits

1 reference

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21 January 2018

(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Cooperative Hairpin Dimers for Recognition of DNA by Pyrrole-Imidazole Polyamides

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Design and synthesis of bis 1-chloromethyl-5-hydroxy-1,2- dihydro-3H-benz[e]indole (seco-CBI)-pyrrole polyamide conjugates

1 reference

https://api.crossref.org/works/10.1039%2FB303650M

21 January 2018

Identifiers

10.1039/B303650M

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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