(Q44582091)

English

Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

scientific article published on 25 July 2013

In more languages

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites (English)

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

Patrick M. Woster

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

author name string

Candace S Hayes

1

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

Karen DeFeo-Mattox

2

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

Susan K Gilmour

4

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

publication date

25 July 2013

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

46

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

3

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

543-552

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

https://scigraph.springernature.com/pub.10.1007/s00726-013-1559-0

0 references

S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Defining the origins of Ras/p53-mediated squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Mammalian polyamine metabolism and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

CD34 expression by hair follicle stem cells is required for skin tumor development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Oxidative stress in the pathogenesis of skin disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Tip60 protein isoforms and altered function in skin and tumors that overexpress ornithine decarboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Capturing and profiling adult hair follicle stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Contribution of stem cells and differentiated cells to epidermal tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

The polyamine oxidase inactivator MDL 72527.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

A definitive role of ornithine decarboxylase in photocarcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Enrichment for murine keratinocyte stem cells based on cell surface phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

K6/ODC transgenic mice as a sensitive model for carcinogen identification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Effect of elevated levels of ornithine decarboxylase on cell cycle progression in skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

30 June 2018

Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

15 August 2018

Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

15 August 2018

Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

15 August 2018

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

15 August 2018

Polyamines regulate expression of the neoplastic phenotype in mouse skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5953903

15 August 2018

Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the epidermal targets of carcinogen action are found in the interfollicular epidermis of infundibulum as well as in the hair follicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal cell cycle and transit times during hyperplastic growth induced by abrasion or treatment with 12-O-tetradecanoylphorbol-13-acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of follicular stem cells in forming not only the follicle but also the epidermis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23884694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00726-013-1559-0

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 June 2018

http://europepmc.org/abstract/PMC/5953903

ResearchGate publication ID

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