(Q34937383)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Defining the origins of Ras/p53-mediated squamous cell carcinoma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

main subject

squamous cell carcinoma

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author name string

Kathy Tran

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Joan Khuu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Christine Dang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Yongyan Cui

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Scott W Binder

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

William E Lowry

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

language of work or name

English

0 references

publication date

18 April 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

29 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

7425-7430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

issue

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

Identifying the cellular origin of squamous skin tumors

29 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Biomarkers for epithelial-mesenchymal transitions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

The basics of epithelial-mesenchymal transition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Oncogenic Kras initiates leukemia in hematopoietic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

A two-step mechanism for stem cell activation during hair regeneration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Crypt stem cells as the cells-of-origin of intestinal cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

The Rb family connects with the Tp53 family in skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Capturing and profiling adult hair follicle stem cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Cutaneous squamous-cell carcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

ras activation in human tumors and in animal model systems

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Molecular determinants of Akt-induced keratinocyte transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

A spatially and temporally restricted mouse model of soft tissue sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088581

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Sunburn and p53 in the onset of skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1012670108

Epidermal stem cells arise from the hair follicle after wounding

21 January 2018

1 reference

12 December 2020

ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation-induced epidermal neoplasias of mouse skin

1 reference

12 December 2020

Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas

1 reference

12 December 2020

The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1 reference

12 December 2020

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

1 reference

12 December 2020

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1012670108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21502519%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference