(Q44591306)

4 December 2017

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape (English)

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4 December 2017

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Victor E. Koteliansky

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Victor Koteliansky

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Marc Bickle

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William Querbes

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Anna Borodovsky

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Giovanni Marsico

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Undine Schubert

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Kevin Manygoats

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Sarah Seifert

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Cordula Andree

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Martin Stöter

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4 December 2017

Hila Epstein-Barash

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Ligang Zhang

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Kevin Fitzgerald

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Eugenio Fava

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Akin Akinc

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Martin Maier

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Marino Zerial

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language of work or name

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23 June 2013

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638-646

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https://scigraph.springernature.com/pub.10.1038/nbt.2612

4 December 2017

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cites work

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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12 December 2020

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

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12 December 2020

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

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12 December 2020

The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells

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12 December 2020

A status report on RNAi therapeutics

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12 December 2020

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.

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12 December 2020

Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology

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12 December 2020

Efficient and targeted delivery of siRNA in vivo

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12 December 2020

Dynasore, a cell-permeable inhibitor of dynamin

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12 December 2020

Enhanced cytoplasmic delivery of siRNA using a stabilized polyion complex based on PEGylated nanogels with a cross-linked polyamine structure.

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12 December 2020

Rab conversion as a mechanism of progression from early to late endosomes

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12 December 2020

Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake

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12 December 2020

Stabilized plasmid-lipid particles: construction and characterization

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12 December 2020

Lipid-like materials for low-dose, in vivo gene silencing

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12 December 2020

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

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12 December 2020

The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms

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12 December 2020

Quantitative evaluation of siRNA delivery in vivo.

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12 December 2020

Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA.

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12 December 2020

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.

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12 December 2020

Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: swelling induced physical disruption of endosome by cold shock.

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12 December 2020

In vivo silencing of alpha-synuclein using naked siRNA

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12 December 2020

Excess vacuolar SNAREs drive lysis and Rab bypass fusion

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12 December 2020

Small RNA sorting: matchmaking for Argonautes.

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12 December 2020

RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.

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12 December 2020

Membrane transport in the endocytic pathway

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12 December 2020

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

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12 December 2020

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation

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12 December 2020

Modulation of thermal stability can enhance the potency of siRNA

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12 December 2020

Sheddable coatings for long-circulating nanoparticles

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12 December 2020

Oligoribonucleotide synthesis. The silyl-phosphoramidite method

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12 December 2020

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.

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12 December 2020

Mechanisms of endocytosis

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12 December 2020

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

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12 December 2020

Rational design of cationic lipids for siRNA delivery

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12 December 2020

Breaking down the barriers: siRNA delivery and endosome escape

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12 December 2020

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

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12 December 2020

Murine cytomegalovirus perturbs endosomal trafficking of major histocompatibility complex class I molecules in the early phase of infection

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12 December 2020

Non-viral vectors for the mediation of RNAi

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12 December 2020

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

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12 December 2020

Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions

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12 December 2020

Novel siRNA delivery system to target podocytes in vivo

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12 December 2020

In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR).

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12 December 2020

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

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12 December 2020

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

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12 December 2020

Identification of the switch in early-to-late endosome transition

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12 December 2020

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

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12 December 2020

Selective gene silencing by viral delivery of short hairpin RNA

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12 December 2020

Identifiers

DOI

10.1038/NBT.2612

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4 December 2017

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