(Q44591611)

4 December 2017

M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase (English)

1 reference

4 December 2017

M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase (English)

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401285

12 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401285

12 March 2024

author name string

H. Glantschnig

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14502240

12 March 2024

J. E. Fisher

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14502240

12 March 2024

G. Wesolowski

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14502240

12 March 2024

G. A. Rodan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14502240

12 March 2024

A. A. Reszka

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14502240

12 March 2024

language of work or name

1 reference

1 October 2003

1 reference

full work available at URL

4 December 2017

https://www.nature.com/articles/4401285.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14502240

http://www.nature.com/articles/4401285

12 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401285

http://www.nature.com/articles/4401285.pdf

12 March 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401285

Cell Death & Differentiation

12 March 2024

published in

1 reference

4 December 2017

10

1 reference

4 December 2017

1165-1177

1 reference

4 December 2017

10

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401285

4 December 2017

0 references

cites work

Bone resorption by osteoclasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Therapeutic approaches to bone diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Regulation of osteoclast formation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Control of apoptosis by Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Kinase regulation in inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Selective sensitization to tumor necrosis factor-alpha-induced apoptosis by blockade of NF-kappaB in primary glomerular mesangial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

The target of rapamycin (TOR) proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphona

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

Isolation and characterization of highly enriched, prefusion mouse osteoclastic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401285

7 January 2021

14

21

115

SC Manolagas

2000

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401285

12 March 2024

41

61

8758

RB Lobell

2001

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401285

12 March 2024

Identifiers

1 reference

4 December 2017

1 reference