(Q44601138)

4 December 2017

title

The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans (English)

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4 December 2017

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Lawrence Fleckenstein

4

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4 December 2017

6

Kenneth R Brown

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4 December 2017

Monette M Cotreau

1

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4 December 2017

Sarah Warren

2

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4 December 2017

John L Ryan

3

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4 December 2017

Sreenivasa R Vanapalli

5

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4 December 2017

David Rock

7

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4 December 2017

Chieh-Yu Chen

8

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4 December 2017

Ullrich S Schwertschlag

9

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4 December 2017

publication date

1 October 2003

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The Journal of Clinical Pharmacology

4 December 2017

published in

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4 December 2017

volume

43

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4 December 2017

issue

10

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4 December 2017

page(s)

1108-1115

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Population biology of human onchocerciasis

4 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

The reproductive lifespan of Onchocerca volvulus in West African savanna

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Immune responsiveness and the pathogenesis of human onchocerciasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Infectious causes of uveitis in the developing world

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Molecular biology and electrophysiology of glutamate-gated chloride channels of invertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Comparison of the pharmacokinetics of moxidectin (Equest) and ivermectin (Eqvalan) in horses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Influence of verapamil on the efflux and metabolism of 14C moxidectin in cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Pharmacokinetics and metabolism of avermectins in livestock

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Reversal of P-glycoprotein-associated multidrug resistance by ivermectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Safety of moxidectin in avermectin-sensitive collies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Frequency of C3435T polymorphism of MDR1 gene in African people

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

Onchocerca volvulus and O. lienalis: the microfilaricidal activity of moxidectin compared with that of ivermectin in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

An electrophysiological preparation of Ascaris suum pharyngeal muscle reveals a glutamate-gated chloride channel sensitive to the avermectin analogue, milbemycin D

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270003257456

21 January 2018

Identifiers

DOI

10.1177/0091270003257456

1 reference

4 December 2017

1 reference