(Q44606335)

4 December 2017

title

Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3. (English)

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4 December 2017

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5

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4 December 2017

Marcus D Säemann

1

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4 December 2017

Christos Diakos

2

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4 December 2017

Peter Kelemen

3

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4 December 2017

Ernst Kriehuber

4

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4 December 2017

Georg A Böhmig

6

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4 December 2017

Walter H Hörl

7

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4 December 2017

Thomas Baumruker

8

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4 December 2017

Gerhard J Zlabinger

9

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4 December 2017

language of work or name

English

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publication date

1 November 2003

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American Journal of Transplantation

4 December 2017

published in

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4 December 2017

volume

3

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4 December 2017

issue

11

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4 December 2017

page(s)

1341-1349

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

4 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Dendritic cells and prospects for transplantation tolerance

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Designer dendritic cells for tolerance induction: guided not misguided missiles

21 January 2018

1 reference

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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

JAK/STAT signaling by cytokine receptors

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Cytokine receptor signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Jaks and Stats in signaling by the cytokine receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

The role of Jak3 in lymphoid development, activation, and signaling

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

21 January 2018

1 reference

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Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

21 January 2018

1 reference

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What's in the pipeline? New immunosuppressive drugs in transplantation

21 January 2018

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Immunobiology of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Dendritic cells in transplantation--friend or foe?

21 January 2018

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Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

21 January 2018

1 reference

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Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Operational tolerance induced by pretreatment with donor dendritic cells under blockade of CD40 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

Targeting Jak3 for immune suppression and allograft acceptance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1600-6143.2003.00225.X

10.1046/J.1600-6143.2003.00225.X

21 January 2018

Identifiers

DOI

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4 December 2017

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