(Q44619780)

4 December 2017

title

Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype (English)

1 reference

Acute myeloblastic leukemia

4 December 2017

main subject

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2403160

21 March 2024

10

R. Suzuki

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

author name string

N. Matsuno

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

M. Osato

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

N. Yamashita

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

M. Yanagida

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

T. Nanri

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

T. Fukushima

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

T. Motoji

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

S. Kusumoto

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

M. Towatari

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

T. Naoe

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

K. Nishii

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

K. Shigesada

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

R. Ohno

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

H. Mitsuya

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

Y. Ito

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

N. Asou

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

21 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14562119

21 March 2024

publication date

1 December 2003

1 reference

full work available at URL

4 December 2017

https://www.nature.com/articles/2403160.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14562119

https://www.nature.com/articles/2403160.pdf

21 March 2024

file format

Portable Document Format

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.LEU.2403160

https://www.nature.com/articles/2403160

21 March 2024

1 reference

DOI

https://api.crossref.org/works/10.1038/SJ.LEU.2403160

21 March 2024

1 reference

4 December 2017

volume

17

1 reference

4 December 2017

issue

12

1 reference

4 December 2017

page(s)

2492-2499

1 reference

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

4 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Core-binding factors in haematopoiesis and leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Disruption of differentiation in human cancer: AML shows the way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

The roles of FLT3 in hematopoiesis and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-MO)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Acute myeloid leukaemia M0: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

Transcription of AML1/ETO in bone marrow and cord blood of individuals without acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

FLT3: ITDoes matter in leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Myelomonoblastic leukaemia cells carrying the PEBP2beta/MYH11 fusion gene are CD34, c-KIT+ immature cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Randomized study of individualized induction therapy with or without vincristine, and of maintenance-intensification therapy between 4 or 12 courses in adult acute myeloid leukemia. AML-87 Study of the Japan Adult Leukemia Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy, and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia. The Japan Leukemia Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

The absence of the p15INK4B gene alterations in adult patients with precursor B-cell acute lymphoblastic leukaemia is a favourable prognostic factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Genomic structure of human FLT3: implications for mutational analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Mutation of the AML1/RUNX1 gene in a transient myeloproliferative disorder patient with Down syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403160

7 January 2021

Identifiers

DOI

1 reference

Dimensions Publication ID

4 December 2017

1051297376

0 references

1 reference