(Q44627784)

4 December 2017

title

Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins (English)

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4 December 2017

1 reference

1 reference

https://api.crossref.org/works/10.1016/S0969-9961(03)00085-8

24 March 2024

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Sang-H Choi

1

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4 December 2017

Jean Kim

4

1 reference

4 December 2017

Da Y. Lee

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14572441

24 March 2024

Jae K. Ryu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14572441

24 March 2024

Eun H. Joe

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14572441

24 March 2024

Byung K. Jin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14572441

24 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14572441

24 March 2024

publication date

1 November 2003

1 reference

full work available at URL

4 December 2017

https://api.elsevier.com/content/article/PII:S0969996103000858?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S0969-9961(03)00085-8

https://api.elsevier.com/content/article/PII:S0969996103000858?httpAccept=text/plain

24 March 2024

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https://api.crossref.org/works/10.1016/S0969-9961(03)00085-8

24 March 2024

published in

Neurobiology of Disease

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4 December 2017

volume

14

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4 December 2017

issue

2

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4 December 2017

page(s)

181-193

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Mechanisms underlying hypoxia-induced neuronal apoptosis

4 December 2017

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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7 January 2021

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism

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7 January 2021

GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures

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7 January 2021

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

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7 January 2021

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

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7 January 2021

Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration

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7 January 2021

Involvement of protease-activated receptor-1 in the in vitro development of mesencephalic dopaminergic neurons.

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7 January 2021

Prothrombin mRNA is expressed by cells of the nervous system.

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7 January 2021

Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons

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7 January 2021

Signaling pathways involved in thrombin-induced cell protection

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7 January 2021

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.

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7 January 2021

Serine proteases and brain damage - is there a link?

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7 January 2021

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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7 January 2021

6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra

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7 January 2021

Glial cells and Parkinson's disease.

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7 January 2021

Involvement of c-Jun N-terminal kinase and caspase 3-like protease in DNA damage-induced, p53-mediated apoptosis of cultured mouse cerebellar granule neurons.

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7 January 2021

Dopamine differentiation factors produce partial motor recovery in 6-hydroxydopamine lesioned rats

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7 January 2021

Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector

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7 January 2021

Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia

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7 January 2021

Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.

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7 January 2021

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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7 January 2021

Enhancement of neurite outgrowth from central nervous system neurons in primary culture by thrombin inhibitors

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7 January 2021

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

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7 January 2021

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

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7 January 2021

Histochemical detection of apoptosis in Parkinson's disease.

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7 January 2021

Thrombin-induced activation of cultured rodent microglia

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7 January 2021

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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7 January 2021

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

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7 January 2021

Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration

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7 January 2021

Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion

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7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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7 January 2021

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7 January 2021

Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B

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7 January 2021

Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia

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7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

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7 January 2021

Neuroprotective signal transduction in model motor neurons exposed to thrombin: G-protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis

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7 January 2021

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

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7 January 2021

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

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7 January 2021

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

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7 January 2021

Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

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7 January 2021

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

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7 January 2021

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

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7 January 2021

Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice

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7 January 2021

Induction of p53 in the glutamate-induced cell death program

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7 January 2021

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

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7 January 2021

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1 reference

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7 January 2021

Histamine Infusion Induces a Selective Dopaminergic Neuronal Death Along with an Inflammatory Reaction in Rat Substantia Nigra

1 reference

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7 January 2021

Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900085-8

7 January 2021

Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900085-8

7 January 2021

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900085-8

7 January 2021

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

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7 January 2021

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

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7 January 2021

Bax involvement in p53-mediated neuronal cell death

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7 January 2021

Acute tissue damage after injections of thrombin and plasmin into rat striatum.

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7 January 2021

Apoptosis in the nervous system

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7 January 2021

Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion

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7 January 2021

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

28

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https://api.crossref.org/works/10.1016/S0969-9961(03)00085-8

Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development

24 March 2024

45

1 reference

https://api.crossref.org/works/10.1016/S0969-9961(03)00085-8

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

24 March 2024

47

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https://api.crossref.org/works/10.1016/S0969-9961(03)00085-8

24 March 2024

Identifiers

1 reference

4 December 2017

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