(Q44644463)

5 December 2017

title

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats (English)

1 reference

5 December 2017

0 references

1 reference

1 reference

https://api.crossref.org/works/10.1007/S00125-003-1246-X

29 March 2024

1

J. B C. Carvalheira

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14600817

29 March 2024

Marcio Alberto Torsoni

6

object named as

M. Torsoni

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29 March 2024

7

J. A R. Gontijo

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29 March 2024

author name string

E. B. Ribeiro

2

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29 March 2024

E. P. Araújo

3

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29 March 2024

R. B. Guimarães

4

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29 March 2024

M. M. Telles

5

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29 March 2024

L. A. Velloso

8

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29 March 2024

M. J A. Saad

9

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29 March 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14600817

29 March 2024

publication date

5 November 2003

1 reference

full work available at URL

5 December 2017

https://link.springer.com/content/pdf/10.1007/s00125-003-1246-x.pdf

file format

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14600817

http://link.springer.com/content/pdf/10.1007/s00125-003-1246-x.pdf

29 March 2024

file format

Portable Document Format

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00125-003-1246-X

http://link.springer.com/article/10.1007/s00125-003-1246-x/fulltext.html

29 March 2024

1 reference

https://api.crossref.org/works/10.1007/S00125-003-1246-X

http://link.springer.com/content/pdf/10.1007/s00125-003-1246-x

29 March 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00125-003-1246-X

29 March 2024

1 reference

5 December 2017

volume

46

1 reference

5 December 2017

issue

12

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5 December 2017

page(s)

1629-1640

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Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats

5 December 2017

cites work

1 reference

12 December 2020

Inhibition of hypothalamic neuropeptide Y gene expression by insulin

1 reference

12 December 2020

Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats

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Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

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Insulin receptors are widely distributed in the central nervous system of the rat

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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Obesity and insulin resistance

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Evaluation of protocols for purification of mouse monoclonal antibodies. Yield and purity in two-dimensional gel electrophoresis

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Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry

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12 December 2020

Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats

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12 December 2020

Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold

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12 December 2020

Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression

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12 December 2020

Reduced effect of experimental peripheral hyperinsulinemia to elevate cerebrospinal fluid insulin concentrations of obese Zucker rats

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12 December 2020

Comparison of immunoglobulin binding capacities and ligand leakage using eight different protein A affinity chromatography matrices

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12 December 2020

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

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12 December 2020

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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12 December 2020

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

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12 December 2020

Signal transduction pathways leading to insulin-induced early gene induction

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12 December 2020

IRS-2 pathways integrate female reproduction and energy homeostasis

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12 December 2020

Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling.

1 reference

12 December 2020

Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis

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12 December 2020

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

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12 December 2020

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

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12 December 2020

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight.

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12 December 2020

Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs

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12 December 2020

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha

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12 December 2020

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

12 December 2020

Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion

1 reference

12 December 2020

Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

12 December 2020

Effect of diet-induced obesity and experimental hyperinsulinemia on insulin uptake into CSF of the rat.

1 reference

12 December 2020

A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans

1 reference

12 December 2020

Localization of insulin receptor mRNA in rat brain by in situ hybridization

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12 December 2020

Role of brain insulin receptor in control of body weight and reproduction

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12 December 2020

Identification of SHC as a substrate of the insulin receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein

1 reference

12 December 2020

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1 reference

12 December 2020

Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats

1 reference

12 December 2020

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

12 December 2020

The Zucker-fatty rat: a review

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12 December 2020

Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver.

1 reference

12 December 2020

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

1 reference

12 December 2020

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

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12 December 2020

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice

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12 December 2020

Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis.

1 reference

12 December 2020

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

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12 December 2020

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain

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12 December 2020

Acute stimulation of glucose metabolism in mice by leptin treatment

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12 December 2020

Role of IRS-2 in insulin and cytokine signalling

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12 December 2020

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1 reference

12 December 2020

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

1 reference

12 December 2020

Brain and liver insulin binding is decreased in Zucker rats carrying the 'fa' gene

1 reference

12 December 2020

Intracellular signalling. Key enzyme in leptin-induced anorexia

1 reference

12 December 2020

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

12 December 2020

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

1 reference

12 December 2020

Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle

1 reference

12 December 2020

Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites

1 reference

12 December 2020

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

1 reference

12 December 2020

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1 reference

12 December 2020

Insulin modulates leptin-induced STAT3 activation in rat hypothalamus.

1 reference

12 December 2020

Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.

1 reference

12 December 2020

Identifiers

DOI

1 reference

5 December 2017

1 reference