(Q44658638)

5 December 2017

title

The active metabolite of leflunomide, an immunosuppressive agent, reduces mechanical sensitivity in a rat mononeuropathy model (English)

1 reference

Anesthesiology and pain medicine

5 December 2017

1 reference

ChEBI release 2020-05-28

ChEBI ID

6402

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

2 April 2024

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

2 April 2024

author name string

Sarah M. Sweitzer

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14622739

2 April 2024

Joyce A. DeLeo

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14622739

2 April 2024

language of work or name

1 reference

1 October 2002

1 reference

full work available at URL

5 December 2017

https://api.elsevier.com/content/article/PII:S1526590002000305?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

https://api.elsevier.com/content/article/PII:S1526590002000305?httpAccept=text/plain

2 April 2024

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

2 April 2024

1 reference

5 December 2017

volume

3

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5 December 2017

issue

5

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5 December 2017

page(s)

360-368

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Nitric oxide signaling in pain and nociceptor sensitization in the rat.

5 December 2017

cites work

1

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain.

2 April 2024

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1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain

2 April 2024

3

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Leflunomide interferes with pyrimidine nucleotide biosynthesis

2 April 2024

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1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat.

2 April 2024

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1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior.

2 April 2024

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1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Tumor necrosis factor-alpha induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor

2 April 2024

11

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Two distinct inwardly rectifying conductances are expressed in long term dibutyryl‐cyclic‐AMP treated rat cultured cortical astrocytes

2 April 2024

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1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials

2 April 2024

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https://api.crossref.org/works/10.1054/JPAI.2002.125181

Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica

2 April 2024

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https://api.crossref.org/works/10.1054/JPAI.2002.125181

Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P

2 April 2024

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Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.

2 April 2024

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Microglial tyrosine phosphorylation systems in normal and degenerating brain

2 April 2024

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Tumour necrosis factor-alpha increases intracellular Ca2+ and induces a depolarization in cultured astroglial cells.

2 April 2024

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https://api.crossref.org/works/10.1054/JPAI.2002.125181

Microglia: a sensor for pathological events in the CNS

2 April 2024

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Cytokine involvement in dynorphin-induced allodynia

2 April 2024

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Local immune regulation in the central nervous system by substance P vs. glutamate

2 April 2024

25

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https://api.crossref.org/works/10.1054/JPAI.2002.125181

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

2 April 2024

26

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes

2 April 2024

27

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Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.

2 April 2024

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Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study

2 April 2024

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Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia

2 April 2024

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1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Expression of immunomolecules on microglial cells following neonatal sciatic nerve axotomy.

2 April 2024

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Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice

2 April 2024

32

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Differential expression of MHC class II antigen in the contused rat spinal cord

2 April 2024

33

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

The role of costimulation in autoimmune demyelination

2 April 2024

34

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

2 April 2024

35

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice

2 April 2024

36

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Induction of interleukin-6 by depolarization of neurons.

2 April 2024

38

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord

2 April 2024

39

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling

2 April 2024

40

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Beneficial immune activity after CNS injury: prospects for vaccination

2 April 2024

42

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat.

2 April 2024

43

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system

2 April 2024

45

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

2 April 2024

Reactive microgliosis

46

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat.

2 April 2024

47

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain

2 April 2024

48

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

The differential role of spinal MHC class II and cellular adhesion molecules in peripheral inflammatory versus neuropathic pain in rodents

2 April 2024

50

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Is IL-6 both a cytokine and a neurotrophic factor?

2 April 2024

51

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.

2 April 2024

52

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

Glial activation: a driving force for pathological pain

2 April 2024

53

1 reference

https://api.crossref.org/works/10.1054/JPAI.2002.125181

2 April 2024

Identifiers

1 reference

5 December 2017

1 reference