(Q44695560)

5 December 2017

title

Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts (English)

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5 December 2017

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Wei-Qin Zhao

1

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5 December 2017

Christina Feng

series ordinal

2

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5 December 2017

Daniel L Alkon

series ordinal

3

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5 December 2017

publication date

1 December 2003

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5 December 2017

published in

Neurobiology of Disease

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5 December 2017

volume

14

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5 December 2017

issue

3

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5 December 2017

page(s)

458-469

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Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.

5 December 2017

cites work

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7 January 2021

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

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7 January 2021

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

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7 January 2021

Role of protein phosphatase 2A in the regulation of mitogen-activated protein kinase activity in ventricular cardiomyocytes

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7 January 2021

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

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7 January 2021

Fibroblast models of neurological disorders: fluorescence measurement studies

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7 January 2021

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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7 January 2021

FKBP ligands as novel therapeutics for neurological disorders

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7 January 2021

Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression

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7 January 2021

Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities

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7 January 2021

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

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7 January 2021

Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

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7 January 2021

Okadaic acid, useful tool for studying cellular processes

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7 January 2021

How regulated protein translocation can produce switch-like responses

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7 January 2021

Growth factors and mitogen-activated protein kinases

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7 January 2021

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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7 January 2021

FK506 and the role of the immunophilin FKBP-52 in nerve regeneration

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7 January 2021

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

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7 January 2021

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

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7 January 2021

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

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7 January 2021

Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells.

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7 January 2021

Real time quantitative PCR

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7 January 2021

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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7 January 2021

Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.

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7 January 2021

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

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7 January 2021

The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin.

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7 January 2021

Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: implications for MAP kinase activation in Alzheimer disease

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7 January 2021

Disruption of the cytoskeleton in Alzheimer's disease

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7 January 2021

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Signal transduction through MAP kinase cascades

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7 January 2021

Bradykinin signalling to MAP kinase: cell-specific connections versus principle mitogenic pathways

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7 January 2021

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

On the structure of microtubules, tau, and paired helical filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Presenilin mutations and calcium signaling defects in the nervous and immune systems

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Protein serine/threonine phosphatases as binding proteins for okadaic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

1 reference

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7 January 2021

Presenilins, Alzheimer's disease, and capacitative calcium entry.

1 reference

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7 January 2021

PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons

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7 January 2021

In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Regulation of transcription by MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain: a molecular substrate for learning and memory?

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

MAP kinase phosphatase 1 is expressed and enhanced by FK506 in surviving mamillary, but not degenerating nigral neurons following axotomy.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Presenilin-mediated modulation of capacitative calcium entry

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

MAP kinase signaling cascade dysfunction specific to Alzheimer's disease in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0969-9961%2803%2900124-4

7 January 2021

10.1016/S0969-9961(03)00124-4

Identifiers

DOI

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5 December 2017

1 reference