(Q44715299)

English

A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for five days every three weeks to patients with metastatic adenocarcinoma of the colon or rectum

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scholarly article

1 reference

Europe PubMed Central

5 December 2017

A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for five days every three weeks to patients with metastatic adenocarcinoma of the colon or rectum (English)

1 reference

Europe PubMed Central

5 December 2017

1 reference

based on heuristic

inferred from title

metastatic adenocarcinoma

1 reference

based on heuristic

inferred from title

Leonard B. Saltz

7

1 reference

Europe PubMed Central

5 December 2017

author name string

Melanie E Royce

1

1 reference

Europe PubMed Central

5 December 2017

Eric K Rowinsky

2

1 reference

Europe PubMed Central

5 December 2017

Paulo M Hoff

3

1 reference

Europe PubMed Central

5 December 2017

John Coyle

4

1 reference

Europe PubMed Central

5 December 2017

Robert DeJager

5

1 reference

Europe PubMed Central

5 December 2017

Richard Pazdur

6

1 reference

Europe PubMed Central

5 December 2017

publication date

1 January 2004

1 reference

Europe PubMed Central

5 December 2017

Investigational New Drugs

1 reference

Europe PubMed Central

5 December 2017

22

1 reference

Europe PubMed Central

5 December 2017

1

1 reference

Europe PubMed Central

5 December 2017

53-61

1 reference

Europe PubMed Central

5 December 2017

https://scigraph.springernature.com/pub.10.1023/b:drug.0000006174.87869.6b

0 references

Antitumour activity of DX-8951f: a new camptothecin derivative.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation study of assay method for DX-8951 and its metabolite in human plasma and urine by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of the camptothecin analog DX-8951f administered as a 30-minute infusion every 3 weeks in patients with advanced cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Fluorouracil by protracted venous infusion. A review of current progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of DX-8951f and topotecan effects on tumor colony formation from freshly explanted adult and pediatric human tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer statistics, 2003.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitive high-performance liquid chromatographic method for the determination of the lactone form and the lactone plus hydroxy-acid forms of the new camptothecin derivative DX-8951 in human plasma using fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimal two-stage designs for phase II clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DX-8951f, a hexacyclic camptothecin analog, on a daily-times-five schedule: a phase I and pharmacokinetic study in patients with advanced solid malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucovorin plus 5-fluorouracil: an effective treatment for metastatic colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The current status of camptothecin analogues as antitumor agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DX-8951f: summary of phase I clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analog

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

US pivotal studies of irinotecan in colorectal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy for metastatic colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/14707494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/B:DRUG.0000006174.87869.6B

1 reference

Europe PubMed Central

5 December 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

5 December 2017

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