(Q44738365)

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Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models

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scholarly article

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Europe PubMed Central

5 December 2017

Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models (English)

1 reference

Europe PubMed Central

5 December 2017

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Crohn's disease

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inferred from title

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10

object named as

P Rutgeerts

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Europe PubMed Central

5 December 2017

author name string

P Maerten

1

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Europe PubMed Central

5 December 2017

C Shen

2

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Europe PubMed Central

5 December 2017

S Colpaert

3

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Europe PubMed Central

5 December 2017

Z Liu

4

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Europe PubMed Central

5 December 2017

D A M Bullens

5

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Europe PubMed Central

5 December 2017

G van Assche

6

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Europe PubMed Central

5 December 2017

F Penninckx

7

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Europe PubMed Central

5 December 2017

K Geboes

8

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Europe PubMed Central

5 December 2017

G Vanham

9

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Europe PubMed Central

5 December 2017

J L Ceuppens

11

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Europe PubMed Central

5 December 2017

publication date

1 February 2004

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Europe PubMed Central

5 December 2017

Clinical and Experimental Immunology

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Europe PubMed Central

5 December 2017

135

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5 December 2017

310-317

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Europe PubMed Central

5 December 2017

2

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Europe PubMed Central

5 December 2017

Inflammatory Bowel Disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Role of cytokines in the pathogenesis of inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Interleukin-18 regulates both Th1 and Th2 responses

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Cloning of a new cytokine that induces IFN-gamma production by T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Chemoattraction of Human T Cells by IL-18

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

An overview of real-time quantitative PCR: applications to quantify cytokine gene expression

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Interleukin-10-deficient mice develop chronic enterocolitis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2004.02362.X

21 January 2018

Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn's disease lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Bioactive IL-18 expression is up-regulated in Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Interleukin 12 and Th1 responses in inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Immunomodulation of Crohn's disease by interleukin-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1808939

3 November 2018

Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum interleukin-18 concentrations in patients with inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro analysis of interferon gamma (IFN-gamma) and interleukin-12 (IL-12) production and their effects in ileal Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hapten-induced model of chronic inflammation and ulceration in the rat colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively

1 reference

https://pubmed.ncbi.nlm.nih.gov/14738461

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2249.2004.02362.X

1 reference

Europe PubMed Central

5 December 2017

0 references

1 reference

Europe PubMed Central

5 December 2017

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