(Q44739415)

5 December 2017

Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors (English)

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5 December 2017

phase I clinical trial

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1

George Wilding

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5 December 2017

David King

2

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5 December 2017

Kendra Tutsch

3

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5 December 2017

Marcia Pomplun

4

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5 December 2017

Chris Feierabend

5

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5 December 2017

Dona Alberti

6

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5 December 2017

Rhoda Arzoomanian

7

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5 December 2017

1 April 2004

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Investigational New Drugs

5 December 2017

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5 December 2017

22

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5 December 2017

131-138

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5 December 2017

2

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https://scigraph.springernature.com/pub.10.1023/b:drug.0000011789.79368.ae

5 December 2017

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cites work

Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines

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12 December 2020

Polyamine metabolism and function

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12 December 2020

Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.

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12 December 2020

Metabolically programmed polyamine analogue antidiarrheals

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12 December 2020

Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression

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12 December 2020

Polyamines in rapid growth and cancer

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12 December 2020

A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer.

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12 December 2020

Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation.

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12 December 2020

Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells.

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12 December 2020

Polyamine analogue antidiarrheals: a structure-activity study

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12 December 2020

Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors

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12 December 2020

Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine

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12 December 2020

Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells

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12 December 2020

Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.

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12 December 2020

Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection

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12 December 2020

Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts

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12 December 2020

The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine

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12 December 2020

Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.

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12 December 2020

Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue

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12 December 2020

Role of polyamines in the control of cell proliferation and differentiation

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12 December 2020

Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine

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12 December 2020

1,4-Diaminobutane (putrescine), spermidine, and spermine

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12 December 2020

Terminally alkylated polyamine analogues as chemotherapeutic agents.

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12 December 2020

Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.

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12 December 2020

Influence of polyamines on membrane functions

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12 December 2020

Polyamines as targets for therapeutic intervention

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12 December 2020

Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells

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12 December 2020

Antiproliferative properties of polyamine analogues: a structure-activity study

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12 December 2020

Metabolism and pharmacokinetics of N1,N14-diethylhomospermine.

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12 December 2020

Effect of N1,N14-bis(ethyl)homospermine on the growth of U-87 MG and SF-126 human brain tumor cells

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12 December 2020

Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues

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12 December 2020

Polyamines are necessary for the survival of human small-cell lung carcinoma in culture

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12 December 2020

Overexpression of ornithine decarboxylase in prostate cancer and prostatic fluid in humans

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12 December 2020

Regulation of polyamine transport in Chinese hamster ovary cells

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12 December 2020

10.1023/B:DRUG.0000011789.79368.AE

Identifiers

DOI

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Dimensions Publication ID

5 December 2017

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