(Q44804017)

6 December 2017

title

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice (English)

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6 December 2017

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Ryo Suzuki

1

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6 December 2017

Kazuyuki Tobe

2

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6 December 2017

Masashi Aoyama

3

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6 December 2017

Atsushi Inoue

4

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6 December 2017

Kentaro Sakamoto

5

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6 December 2017

Toshimasa Yamauchi

6

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6 December 2017

Junji Kamon

7

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6 December 2017

Naoto Kubota

8

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6 December 2017

Yasuo Terauchi

9

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6 December 2017

Hironobu Yoshimatsu

10

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6 December 2017

Munehide Matsuhisa

11

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6 December 2017

Shoichiro Nagasaka

12

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6 December 2017

Hitomi Ogata

13

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6 December 2017

Kumpei Tokuyama

14

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6 December 2017

Ryozo Nagai

15

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6 December 2017

Takashi Kadowaki

16

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6 December 2017

language of work or name

English

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publication date

17 March 2004

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Journal of Biological Chemistry

6 December 2017

published in

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6 December 2017

volume

279

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6 December 2017

issue

24

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6 December 2017

page(s)

25039-25049

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

6 December 2017

cites work

1 reference

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Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

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The hormone resistin links obesity to diabetes

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Signaling pathways in insulin action: molecular targets of insulin resistance

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A futile metabolic cycle activated in adipocytes by antidiabetic agents

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

21 January 2018

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The IRS-signalling system: a network of docking proteins that mediate insulin action

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Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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Role of IRS-2 in insulin and cytokine signalling

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The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

21 January 2018

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A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

21 January 2018

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

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Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.

21 January 2018

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4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

21 January 2018

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Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

21 January 2018

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Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease

21 January 2018

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Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

21 January 2018

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Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

21 January 2018

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21 January 2018

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Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action.

21 January 2018

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Leptin selectively decreases visceral adiposity and enhances insulin action.

21 January 2018

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Serum immunoreactive-leptin concentrations in normal-weight and obese humans

21 January 2018

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Obesity and the regulation of energy balance

21 January 2018

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Endogenous glucose production and glucose effectiveness in type 2 diabetic subjects derived from stable-labeled minimal model approach.

21 January 2018

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Brain-derived neurotrophic factor ameliorates hepatic insulin resistance in Zucker fatty rats

21 January 2018

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Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice

21 January 2018

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Role of brain insulin receptor in control of body weight and reproduction

21 January 2018

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Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

21 January 2018

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Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance

21 January 2018

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Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311956200

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Short-Term Leptin-Dependent Inhibition of Hepatic Gluconeogenesis Is Mediated by Insulin Receptor Substrate-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311956200

IRS-2 pathways integrate female reproduction and energy homeostasis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311956200

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311956200

21 January 2018

Identifiers

DOI

10.1074/JBC.M311956200

1 reference

6 December 2017

1 reference