(Q44826580)

6 December 2017

title

FTY720 (fingolimod) attenuates beta-amyloid peptide (Aβ42)-induced impairment of spatial learning and memory in rats (English)

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6 December 2017

5

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6 December 2017

Masoumeh Asle-Rousta

1

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6 December 2017

Zeynab Kolahdooz

series ordinal

2

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6 December 2017

Shahrbanoo Oryan

series ordinal

3

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6 December 2017

Abolhassan Ahmadiani

series ordinal

4

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6 December 2017

publication date

26 February 2013

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Journal of Molecular Neuroscience

6 December 2017

published in

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6 December 2017

volume

50

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6 December 2017

issue

3

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6 December 2017

page(s)

524-532

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Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

6 December 2017

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21 January 2018

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

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Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis

21 January 2018

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

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Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis

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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

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Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease

21 January 2018

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

21 January 2018

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Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages

21 January 2018

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Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide

21 January 2018

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Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons

21 January 2018

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Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

21 January 2018

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Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.

21 January 2018

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Deregulation of sphingolipid metabolism in Alzheimer's disease

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New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets

21 January 2018

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Fingolimod modulates microglial activation to augment markers of remyelination

21 January 2018

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Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease

21 January 2018

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Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons

21 January 2018

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Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.

21 January 2018

1 reference

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Correlation of beta-amyloid aggregate size and hydrophobicity with decreased bilayer fluidity of model membranes

21 January 2018

1 reference

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The metabolism and function of sphingolipids and glycosphingolipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia

21 January 2018

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Central nervous system-directed effects of FTY720 (fingolimod).

21 January 2018

1 reference

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Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats.

21 January 2018

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Alzheimer's disease amyloid beta-protein and synaptic function

21 January 2018

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

21 January 2018

1 reference

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The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

The interaction of beta-amyloid protein with cellular membranes stimulates its own production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Sphingosine 1-phosphate, a key cell signaling molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Fingolimod provides long-term protection in rodent models of cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Apoptosis in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12031-013-9979-6

Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

21 January 2018

1 reference

12 December 2020

Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed

1 reference

12 December 2020

Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases

1 reference

12 December 2020

A review: inflammatory process in Alzheimer's disease, role of cytokines.

1 reference

12 December 2020

10.1007/S12031-013-9979-6

Identifiers

DOI

1 reference

6 December 2017

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