(Q35154946)

6 August 2017

title

Fingolimod modulates microglial activation to augment markers of remyelination (English)

1 reference

6 August 2017

0 references

2

Gavin Giovannoni

1 reference

6 August 2017

Samuel J Jackson

1

1 reference

6 August 2017

David Baker

series ordinal

3

1 reference

6 August 2017

publication date

5 July 2011

1 reference

Journal of Neuroinflammation

6 August 2017

published in

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6 August 2017

volume

8

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6 August 2017

page(s)

76

1 reference

Fingolimod provides long-term protection in rodent models of cerebral ischemia

6 August 2017

cites work

1 reference

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13 July 2018

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Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions

13 July 2018

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Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices.

13 July 2018

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Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis

13 July 2018

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Overcoming remyelination failure in multiple sclerosis and other myelin disorders

13 July 2018

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What is the optimal value of the g-ratio for myelinated fibers in the rat CNS? A theoretical approach

13 July 2018

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FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses

13 July 2018

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Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

13 July 2018

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Sphingosine 1-phosphate receptor signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Lysophosphatidylcholine induces glial cell activation: role of rho kinase

13 July 2018

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Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system

13 July 2018

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Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod.

13 July 2018

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Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies.

13 July 2018

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FTY720 modulates human oligodendrocyte progenitor process extension and survival.

13 July 2018

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

13 July 2018

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Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Oral fingolimod (FTY720) for relapsing multiple sclerosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Cannabinoids and neuroprotection in CNS inflammatory disease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Cytotoxic actions of FTY720, a novel immunosuppressant, on thymocytes and brain neurons dissociated from the rat.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Myelination and remyelination of aggregate rat brain cell cultures enriched with macrophages.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Saltatory conduction precedes remyelination in axons demyelinated with lysophosphatidyl choline

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Maintenance of myelinated fibre g ratio in acute experimental allergic encephalomyelitis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Morphological differentiation of mechanically dissociated fetal rat brain in aggregating cell cultures

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer

13 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Quantitative determination of BAF312, a S1P-R modulator, in human urine by LC-MS/MS: prevention and recovery of lost analyte due to container surface adsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

An in vitro model for de- and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Developmental changes in the basic proteins of normal and jimpy mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Study of expression of myelin basic proteins (MBPs) in developing rat brain using a novel antibody reacting with four major isoforms of MBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Remyelination of cytokine- or antibody-demyelinated CNS aggregate cultures is inhibited by macrophage supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Microglial activation state and lysophospholipid acid receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: effects of macrophage enrichment

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3152910

T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS

27 September 2018

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-8-76

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

12 December 2020

Remyelination of mouse spinal cord axons demyelinated by local injection of lysolecithin

1 reference

12 December 2020

Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720

1 reference

12 December 2020

Cannabinoid-mediated neuroprotection following interferon-gamma treatment in a three-dimensional mouse brain aggregate cell culture

1 reference

12 December 2020

Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation

1 reference

12 December 2020

Identifiers

DOI

10.1186/1742-2094-8-76

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference

6 August 2017

1 reference