(Q44894528)

7 December 2017

title

Metabolic studies on haloperidol and its tetrahydropyridinyl dehydration product (HPTP) in C57BL/6 mouse brain preparations (English)

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7 December 2017

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Etsuko Usuki

1

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7 December 2017

Jeffrey R Bloomquist

2

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7 December 2017

Ethan Freeborn

3

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7 December 2017

Kay Casagnoli

4

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7 December 2017

Cornelis J Van Der Schyf

5

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7 December 2017

Neal Castagnoli

6

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7 December 2017

publication date

1 February 2002

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7 December 2017

published in

Neurotoxicity Research

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7 December 2017

volume

4

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7 December 2017

issue

1

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7 December 2017

page(s)

51-58

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Iron-mediated bioactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in glial cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Tardive dyskinesia. A discontinuation study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Clinical and neuropathological abnormalities in baboons treated with HPTP, the tetrahydropyridine analog of haloperidol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Studies on the metabolism of haloperidol (HP): the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Tardive dyskinesia: review and update

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Assessment of structural requirements for the monoamine oxidase-B-catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Correlation of vacuous chewing movements with morphological changes in rats following 1-year treatment with haloperidol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Research and society: a relationship with two faces

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Modulation of MDR1 and CYP3A expression by dexamethasone: evidence for an inverse regulation in adrenals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

The relationship between serum concentration and therapeutic effect of haloperidol in patients with acute schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurotoxic pyridinium metabolites by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Metabolism of haloperidol and its tetrahydropyridine dehydration product HPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Metabolic studies on haloperidol and its tetrahydropyridine analog in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10298420290007628

Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon

21 January 2018

1 reference

12 December 2020

Effect of haloperidol and its metabolites on dopamine and noradrenaline uptake in rat brain slices

1 reference

12 December 2020

Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: is HPTP an intermediate?

1 reference

12 December 2020

Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives

1 reference

12 December 2020

Chronic antagonist treatment does not alter the mode of interaction of dopamine with rat striatal dopamine receptors

1 reference

12 December 2020

Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins.

1 reference

12 December 2020

Determination of the pyridinium metabolite derived from haloperidol in brain tissue, plasma and urine by high-performance liquid chromatography with fluorescence detection

1 reference

12 December 2020

Tardive dyskinesia: pathophysiology and animal models.

1 reference

12 December 2020

Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells

1 reference

12 December 2020

MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies

1 reference

12 December 2020

1 reference

12 December 2020

Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats

1 reference

12 December 2020

1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies

1 reference

12 December 2020

Preparation of the flavin-containing aromatic amine oxidases of human placenta and beef liver

1 reference

12 December 2020

Chemistry and Pharmacology of CNS Depressants Related to 4-(4-Hydroxy-4-phenylpiperidino)butyrophenone Part I--Synthesis and screening data in mice

1 reference

12 December 2020

Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia

1 reference

12 December 2020

Dehydration is the first step in the bioactivation of haloperidol to its pyridinium metabolite

1 reference

12 December 2020

In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology

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12 December 2020

The preparation of microsomes

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12 December 2020

10.1080/10298420290007628

Identifiers

DOI

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Dimensions Publication ID

7 December 2017

1029045980

0 references

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