(Q44914263)

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Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.

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Europe PubMed Central

7 December 2017

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Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine

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Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2. (English)

1 reference

stated in

Europe PubMed Central

7 December 2017

1 reference

1 reference

Girija Dasmahapatra

1

1 reference

stated in

Europe PubMed Central

PubMed ID

16219908

retrieved

7 December 2017

Jorge A Almenara

series ordinal

2

1 reference

stated in

Europe PubMed Central

PubMed ID

16219908

retrieved

7 December 2017

Steven Grant

series ordinal

3

1 reference

stated in

Europe PubMed Central

7 December 2017

11 October 2005

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stated in

Europe PubMed Central

7 December 2017

Molecular Pharmacology

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Europe PubMed Central

7 December 2017

69

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Europe PubMed Central

7 December 2017

288-298

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Europe PubMed Central

7 December 2017

1

1 reference

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Europe PubMed Central

7 December 2017

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Critical role of reactive oxygen species and mitochondrial membrane potential in Korean mistletoe lectin-induced apoptosis in human hepatocarcinoma cells

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Leukemia fusion proteins and co-repressor complexes: changing paradigms

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Histone deacetylases, transcriptional control, and cancer

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Death by design: apoptosis, necrosis and autophagy

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Histone acetylation and deacetylation in yeast

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Cell death: critical control points

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Clinical development of histone deacetylase inhibitors as anticancer agents

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/references/10.1124/MOL.105.016154

Identifiers

DOI

10.1124/MOL.105.016154

1 reference

stated in

Europe PubMed Central

7 December 2017

1 reference

Europe PubMed Central

PubMed ID

16219908

retrieved

7 December 2017

ResearchGate publication ID

7546061

0 references

(Q44914263)

Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.

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